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Post-stroke sleep disturbance/insomnia is associated with female sex, anxiety, depression, and heart disease in stroke survivors

This meta-analysis of 13 studies (6,109 stroke survivors) found that female patients and those with anxiety, depression, or heart disease had significantly higher odds of post-stroke sleep disturbance/insomnia. Sleep disturbance/insomnia was more pronounced during follow-up beyond 3 months post-stroke.

Last updated: Aug 26, 2026•0 RCTs•1 Meta-analyses•📖 Read as article →

Evidence Score

Evidence Score49/100
Human RCT☆☆☆☆☆
Meta-analysis★★★☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Insomnia and Sleep Disturbance in Stroke Survivors: A Meta-Analysis of Prevalence, Risk Factors, and Recovery Outcomes in Ischemic and Hemorrhagic Stroke Survivors.

observational

Mogombaye NG, Jagdewsing D, Elijah W, Rashidi F, Rashidi M, Moharam H, Jagdewsing S, Angel, Iqbal F, Liu L · Cureus (2026)

Participants: N/A
Duration: N/A (follow-up varied; >3 months subgroup)
Intervention: N/A (observational meta-analysis; no intervention tested)
Outcome: Prevalence of post-stroke sleep disturbance/insomnia, odds ratios for associated risk factors
Effect Size: N/A (pooled ORs reported but specific values not in abstract)
Population: Adult stroke survivors (ischemic and hemorrhagic) from 13 observational studies

Result:

PubMed: 42639432DOI: 10.7759/cureus.113184

Mechanism Graph

Stroke causes neurological damage affecting sleep-regulating brain regions
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Psychological comorbidities (anxiety, depression) exacerbate sleep disruption
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Cardiovascular conditions contribute to physiological stress and sleep impairment
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Result: Increased prevalence of insomnia/sleep disturbance in vulnerable subgroups

Limitations

  • ⚠Only 13 studies included, limiting generalizability
  • ⚠Heterogeneity in sleep disturbance definitions and diagnostic methods across studies
  • ⚠Subgroup analyses may be underpowered for some comparisons
  • ⚠Potential publication bias not addressed in abstract

Frequently Asked Questions

What is the prevalence of sleep disturbance after stroke?▼

The abstract does not report a specific pooled prevalence percentage, but it states that post-stroke sleep disturbance/insomnia is prevalent and under-recognized, affecting recovery and quality of life.

Which stroke survivors are at highest risk for insomnia?▼

Female stroke survivors and those with anxiety, depression, or heart disease have significantly higher odds of post-stroke sleep disturbance/insomnia.

Does sleep disturbance differ between ischemic and hemorrhagic stroke?▼

The abstract mentions that the meta-analysis aimed to compare rates between ischemic and hemorrhagic stroke, but no specific comparative results are reported in the abstract.

When does post-stroke insomnia typically occur?▼

Sleep disturbance/insomnia was more pronounced during later follow-up (greater than 3 months post-stroke), suggesting it may persist or emerge over time.

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References

  1. 1.Mogombaye NG, Jagdewsing D, Elijah W, Rashidi F, Rashidi M, Moharam H, Jagdewsing S, Angel, Iqbal F, Liu L. "Insomnia and Sleep Disturbance in Stroke Survivors: A Meta-Analysis of Prevalence, Risk Factors, and Recovery Outcomes in Ischemic and Hemorrhagic Stroke Survivors.." Cureus, 2026. PMID: 42639432 DOI: 10.7759/cureus.113184
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