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Preoperative ultrasound-guided stellate ganglion block reduces the incidence and severity of postoperative sore throat after thoracic surgery with double-lumen endobronchial tubes

This study protocol describes a double-blind RCT testing whether preoperative ultrasound-guided SGB with 0.25% ropivacaine 4mL reduces POST incidence at 6 hours postoperatively compared to saline placebo in 132 patients undergoing thoracoscopic resection with DLTs. Secondary outcomes include POST severity at multiple time points, pain scores, nausea/vomiting, hoarseness, recovery quality, sleep quality, and analgesic consumption.

Last updated: Jul 16, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Preoperative Ultrasound-Guided Stellate Ganglion Block for Prevention of Postoperative Sore Throat After Thoracic Surgery: Study Protocol for a Randomized Controlled Trial.

observational

Wang L, Yan X, Jiang J, Wu A · Journal of pain research (2026)

Participants: N/A
Duration: 48 hours postoperative follow-up
Intervention: Preoperative ultrasound-guided stellate ganglion block with 0.25% ropivacaine 4mL at C6 level on the same side as thoracic surgery
Outcome: Incidence of postoperative sore throat at 6 hours postoperatively; also severity at 1, 24, and 48 hours, NRS pain scores, PONV, hoarseness, QoR-15, RCSQ sleep score, PCIA dosage
Effect Size: N/A
Population: Patients undergoing thoracoscopic resection of pulmonary lobes/segments with double-lumen endobronchial tubes

Result:

PubMed: 42445935DOI: 10.2147/JPR.S612817

Mechanism Graph

SGB blocks sympathetic innervation to the head, neck, and upper airway
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Reduces airway inflammation and edema
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Modulates sympathetic tone and pain signaling
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Decreases incidence and severity of postoperative sore throat

Limitations

  • ⚠Study protocol only; results not yet available
  • ⚠Single-center design may limit generalizability
  • ⚠Placebo-controlled but does not account for potential systemic effects of local anesthetic

Frequently Asked Questions

What is the primary outcome of this trial?▼

The primary outcome is the incidence of postoperative sore throat at 6 hours after surgery.

How many patients will be enrolled?▼

A total of 132 patients will be randomized into two groups.

What type of block is being tested?▼

Ultrasound-guided stellate ganglion block at the C6 level using 0.25% ropivacaine.

Is this study completed?▼

No, this is a study protocol; the trial is not yet completed and results are not available.

Products

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References

  1. 1.Wang L, Yan X, Jiang J, Wu A. "Preoperative Ultrasound-Guided Stellate Ganglion Block for Prevention of Postoperative Sore Throat After Thoracic Surgery: Study Protocol for a Randomized Controlled Trial.." Journal of pain research, 2026. PMID: 42445935 DOI: 10.2147/JPR.S612817
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.