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Probiotics containing L. brevis KABP052 increase circulating estrogens in postmenopausal women

A 12-week intervention with probiotics containing L. brevis KABP052 increased circulating estrogen levels by up to 26% in postmenopausal women, suggesting gut microbiome modulation can enhance endogenous estrogen activity. This provides a non-pharmacological strategy for managing estrogen decline.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Natural strategies to optimize estrogen levels in aging women: mini review.

observational

Bolgova O, Shypilova I, Mavrych V · Frontiers in aging (2025)

Participants: N/A
Duration: 12 weeks
Intervention: Probiotics containing L. brevis KABP052
Outcome: Circulating estrogen levels
Effect Size: 26% increase
Population: Postmenopausal women

Result:

PubMed: 41377590DOI: 10.3389/fragi.2025.1706117

Mechanism Graph

Probiotics containing L. brevis KABP052 are administered
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Gut microbiome composition is altered
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Beta-glucuronidase activity from specific bacterial strains increases
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Deconjugation of estrogen metabolites enhances enterohepatic recirculation
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Result: Circulating estrogen levels rise by up to 26%

Limitations

  • ⚠Dosing regimen not specified in abstract
  • ⚠Genetic variability and individual microbiome differences may affect outcomes
  • ⚠Long-term safety and efficacy beyond 12 weeks not addressed

Frequently Asked Questions

How much did estrogen levels increase with L. brevis KABP052 probiotics?▼

Circulating estrogens increased by up to 26% over 12 weeks.

What is the mechanism by which probiotics increase estrogen?▼

Probiotics like L. brevis KABP052 may enhance beta-glucuronidase activity in the gut, leading to deconjugation and reabsorption of estrogen metabolites, thereby increasing circulating estrogen levels.

Are probiotics a safe alternative to hormone therapy for menopausal symptoms?▼

The abstract suggests probiotics are a natural alternative, but it notes that natural approaches cannot fully replace hormone therapy. Safety data beyond 12 weeks are not provided.

What other natural interventions were effective for menopausal symptoms?▼

Dietary phytoestrogens (50-80 mg/day isoflavones) reduced severe hot flashes by up to 92%, curcumin (500 mg/day) reduced hot flashes after 4 weeks, and resveratrol (75 mg twice daily) improved bone mineral density over 12 months.

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References

  1. 1.Bolgova O, Shypilova I, Mavrych V. "Natural strategies to optimize estrogen levels in aging women: mini review.." Frontiers in aging, 2025. PMID: 41377590 DOI: 10.3389/fragi.2025.1706117
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.