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Si Ni Powder enhances doxorubicin efficacy in sleep-deprived breast cancer by modulating the tumor microenvironment

In an orthotopic 4T1 breast cancer mouse model, sleep deprivation weakened the antitumor effect of doxorubicin, which was effectively rescued by Si Ni Powder. SNP counteracted SD-induced inflammatory signaling, extracellular matrix remodeling, and lipid metabolic pathways, with 168 chemical components identified and 20 detected in tumor tissues.

Last updated: Jul 27, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score24/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Si Ni Powder enhances chemotherapy efficacy in sleep-deprived breast cancer via modulation of the tumor microenvironment.

observational

Jia H, Chen Y, Cheng H, Yao S, Wang Q, Qian M, Ge C, Huang Z, Chen Y · Translational cancer research (2026)

Participants: N/A
Duration: N/A
Intervention: Si Ni Powder (SNP) administered alongside doxorubicin in sleep-deprived mice
Outcome: Tumor growth, serum melatonin and cortisol levels, tumor microenvironment remodeling (inflammation, ECM, lipid metabolism)
Effect Size: N/A
Population: Orthotopic 4T1 breast cancer mouse model with sleep deprivation

Result:

PubMed: 42445414DOI: 10.21037/tcr-2026-0517

Mechanism Graph

SD activates inflammatory signaling, ECM remodeling, and lipid metabolic pathways in TME
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SNP-derived compounds (e.g., neoeriocitrin, genistein) bind to key targets (Stat3, Stat6, Ppara, Rxra, Ar, Hes1)
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SNP suppresses inflammation, normalizes ECM, and reprograms lipid metabolism
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Result: Enhanced doxorubicin efficacy and reduced chemoresistance

Limitations

  • ⚠Animal model only; results may not directly translate to humans
  • ⚠Specific dose and administration regimen of SNP not reported in abstract

Frequently Asked Questions

What is Si Ni Powder?▼

Si Ni Powder is a traditional Chinese medicine formulation known for sleep-improving properties, tested here for its ability to enhance chemotherapy in sleep-deprived breast cancer.

How does sleep deprivation affect chemotherapy?▼

Sleep deprivation weakens the antitumor effect of doxorubicin by activating inflammatory signaling, extracellular matrix remodeling, and lipid metabolic pathways in the tumor microenvironment.

What are the key molecular targets of SNP?▼

Integrated analyses identified six key targets: Stat3, Stat6, Ppara, Rxra, Ar, and Hes1, with strong interactions from compounds like neoeriocitrin and genistein.

Is this study in humans or animals?▼

This study used an orthotopic 4T1 breast cancer mouse model, so it is preclinical animal research.

Products

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References

  1. 1.Jia H, Chen Y, Cheng H, Yao S, Wang Q, Qian M, Ge C, Huang Z, Chen Y. "Si Ni Powder enhances chemotherapy efficacy in sleep-deprived breast cancer via modulation of the tumor microenvironment.." Translational cancer research, 2026. PMID: 42445414 DOI: 10.21037/tcr-2026-0517
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.