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Site-related variance in MRI measures is generally small (typically <10%) in the AMP SCZ multi-site neuroimaging protocol, but platform-related variance is substantial for diffusion imaging SNR/CNR (>55%) and spatial smoothness.

In the AMP SCZ multi-site neuroimaging protocol, site-related variance is generally small (typically <10%) for most MRI measures. However, for diffusion-weighted imaging, platform-related variance accounts for >55% of the variance in signal-to-noise and contrast-to-noise ratios due to hardware differences, and spatial smoothness also shows large platform-related variance.

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism☆☆☆☆☆
Safety☆☆☆☆☆
Confidencelow

Study Evidence

Study 1. The MR neuroimaging protocol for the Accelerating Medicines Partnership&#xae; Schizophrenia Program.

observational

Harms MP, Cho KK, Anticevic A, Bolo NR, Bouix S, Campbell D, Cannon TD, Cecchi G, Goncalves M, Haidar A, Hughes DE, Izyurov I, John O, Kapur T, Kim N, Kotler E, Kubicki M, Kuperman JM, Laulette K, Lindberg U, Markiewicz C, Ning L, Poldrack RA, Rathi Y, Romo PA, Tamayo Z, Wannan C, Wickham A, Yassin W, Zhou JH, Addington J, Alameda L, Arango C, Breitborde NJK, Broome MR, Cadenhead KS, Calkins ME, Chen EYH, Choi J, Conus P, Corcoran CM, Cornblatt BA, Diaz-Caneja CM, Ellman LM, Fusar-Poli P, Gaspar PA, Gerber C, Glenth&#xf8;j LB, Horton LE, Hui CLM, Kambeitz J, Kambeitz-Ilankovic L, Keshavan MS, Kim SW, Koutsouleris N, Kwon JS, Langbein K, Mamah D, Mathalon DH, Mittal VA, Nordentoft M, Pearlson GD, Perez J, Perkins DO, Powers AR, Rogers J, Sabb FW, Schiffman J, Shah JL, Silverstein SM, Smesny S, Stone WS, Strauss GP, Thompson JL, Upthegrove R, Verma SK, Wang J, Wolf DH, Kahn RS, Kane JM, McGorry PD, Nelson B, Woods SW, Shenton ME, Wood SJ, Bearden CE, Pasternak O · Schizophrenia (Heidelberg, Germany) (2026)

Participants: N/A
Duration: 2 months (two time points)
Intervention: Multi-site, multi-vendor MRI neuroimaging protocol (T1/T2 structural, resting-state fMRI, diffusion-weighted imaging) with two time points ~2 months apart
Outcome: Variance components (participant, site, platform) for signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and spatial smoothness
Effect Size: N/A
Population: Individuals at clinical high risk (CHR) for developing psychosis (part of the AMP SCZ cohort)

Result:

PubMed: 40175382DOI: 10.1038/s41537-025-00581-6

Mechanism Graph

Multi-site MRI data collected from different scanner models
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Variance component analysis performed on SNR/CNR and spatial smoothness
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Site-related variance found to be small (<10%) for most measures
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Platform-related variance dominates for diffusion imaging (>55%) and spatial smoothness

Limitations

  • ⚠Preliminary variance component analyses only; full cohort results not yet available
  • ⚠Platform-related variance may limit generalizability of diffusion imaging findings across scanner types

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References

  1. 1.Harms MP, Cho KK, Anticevic A, Bolo NR, Bouix S, Campbell D, Cannon TD, Cecchi G, Goncalves M, Haidar A, Hughes DE, Izyurov I, John O, Kapur T, Kim N, Kotler E, Kubicki M, Kuperman JM, Laulette K, Lindberg U, Markiewicz C, Ning L, Poldrack RA, Rathi Y, Romo PA, Tamayo Z, Wannan C, Wickham A, Yassin W, Zhou JH, Addington J, Alameda L, Arango C, Breitborde NJK, Broome MR, Cadenhead KS, Calkins ME, Chen EYH, Choi J, Conus P, Corcoran CM, Cornblatt BA, Diaz-Caneja CM, Ellman LM, Fusar-Poli P, Gaspar PA, Gerber C, Glenth&#xf8;j LB, Horton LE, Hui CLM, Kambeitz J, Kambeitz-Ilankovic L, Keshavan MS, Kim SW, Koutsouleris N, Kwon JS, Langbein K, Mamah D, Mathalon DH, Mittal VA, Nordentoft M, Pearlson GD, Perez J, Perkins DO, Powers AR, Rogers J, Sabb FW, Schiffman J, Shah JL, Silverstein SM, Smesny S, Stone WS, Strauss GP, Thompson JL, Upthegrove R, Verma SK, Wang J, Wolf DH, Kahn RS, Kane JM, McGorry PD, Nelson B, Woods SW, Shenton ME, Wood SJ, Bearden CE, Pasternak O. "The MR neuroimaging protocol for the Accelerating Medicines Partnership&#xae; Schizophrenia Program.." Schizophrenia (Heidelberg, Germany), 2026. PMID: 40175382 DOI: 10.1038/s41537-025-00581-6
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.