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Sleep intervention shows effects in research

Exploring the Prevalence and Key Predictors of Probable Depression Among Parents and Primary Caregivers of Children and Adolescents With Specific Learning Disorders in the Kingdom of Saudi Arabia: A Cross-Sectional Explainable Machine-Learning Study.. Published in Clinical psychology & psychotherapy (2026). PMID: 42490731.

Last updated: Jul 26, 20260 RCTs📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★
Confidencelow

Study Evidence

Study 1. Sleep quality after endovenous ablation with concomitant phlebectomy in patients with chronic venous disease: A prospective observational study in Vietnam.

observational

Huyen Trang HN, Vy HT, Cam Van NN, Hong Anh VT, Kieu Nga PT, Hoa HN, Kim Thao VT, Thanh Truc NT, Bang HT · Journal of vascular surgery cases and innovative techniques (2026)

Participants: 77
Duration: 1 month
Intervention: Endovenous ablation (frequently combined with phlebectomy)
Outcome: Sleep quality measured by Pittsburgh Sleep Quality Index (PSQI) global and component scores
Effect Size: N/A
Population: 77 patients with lower extremity chronic venous disease (CVD) undergoing endovenous ablation in Vietnam

Result: In a prospective observational study of 77 patients with lower extremity CVD, endovenous ablation (frequently combined with phlebectomy) was associated with significant improvement in sleep quality at 1-month follow-up. The median PSQI score decreased from 6 to 5 (P < .001), and the proportion of patients with poor sleep quality (PSQI > 5) declined from 66.2% to 41.6%.

Study 2. Diagnostic Tools in Sleep Medicine.

observational

Yuan N, Avidan AY · The Medical clinics of North America (2026)

Participants: N/A
Duration: N/A
Intervention: Structured diagnostic approach integrating clinical data, subjective assessments, and objective measures
Outcome: Accurate diagnosis and management of sleep disorders
Effect Size: N/A
Population: Patients with common sleep disorders (insomnia, hypersomnolence disorders, obstructive sleep apnea, circadian rhythm sleep-wake disorders)

Result: The paper presents a structured approach to diagnosing sleep disorders, emphasizing the combination of clinical data, validated screening instruments, objective diagnostic modalities, physical examination, and targeted biomarkers. This integrative method supports accurate diagnosis and management of insomnia, hypersomnolence disorders, obstructive sleep apnea, and circadian rhythm sleep-wake disorders.

Study 3. Sleep disturbances in tension-type headache: a systematic review and meta-analysis.

meta

Yuan L, Kulachai P, Wu QM, Zhang YX, Niu XY, Liang JT, Zheng H · Journal of neurology (2026)

Participants: 27
Duration: N/A
Intervention: None (observational study of sleep outcomes in TTH)
Outcome: Prevalence of poor sleep quality (PSQI >5), mean PSQI score, sleep duration, insomnia, excessive daytime sleepiness, OSA risk
Effect Size: Pooled prevalence 67% (95% CI 53-79%); mean difference in PSQI vs controls = 3.77 (95% CI 2.32-5.22); correlation with depression r=0.51
Population: Adults with tension-type headache (TTH) from 27 observational studies

Result: The pooled prevalence of poor sleep quality (PSQI >5) in adults with tension-type headache was 67% (95% CI 53-79%). The mean PSQI score was 9.48, significantly higher than controls (mean difference 3.77, 95% CI 2.32-5.22), and correlated robustly with depression (r=0.51).

Study 4. Exploring the Prevalence and Key Predictors of Probable Depression Among Parents and Primary Caregivers of Children and Adolescents With Specific Learning Disorders in the Kingdom of Saudi Arabia: A Cross-Sectional Explainable Machine-Learning Study.

observational

Almulla AA, Khasawneh MAS · Clinical psychology &amp; psychotherapy (2026)

Participants: 612
Duration: cross-sectional
Intervention: Explainable machine-learning models (Elastic-net, Random Forest, XGBoost, LightGBM, soft-voting ensemble) for screening-oriented classification of probable depression
Outcome: Probable depression defined as PHQ-9 score ≥ 10, model performance (ROC AUC, average precision, Brier score, sensitivity, specificity, negative predictive value)
Effect Size: N/A
Population: 612 parents and primary caregivers of children and adolescents with specific learning disorders in Saudi Arabia, recruited through clinical, psychoeducational, educational, and community pathways

Result: The study found that 35.6% of 612 caregivers met criteria for probable depression (PHQ-9 ≥ 10). XGBoost achieved an ROC AUC of 0.916, sensitivity of 0.858, and specificity of 0.830 at a screening threshold of 0.425, with key predictors including parenting stress, anxiety, sleep quality, and child difficulties.

Study 5. Do power naps save sleepiness? Cognitive benefits of brief sleep during a 100 miles ultramarathon.

observational

Bourlois V, Boulagnon A, Elsworth-Edelsten C, Ceugniez M, Claeyssen C, Smith M, Comont L, Clergue J, Baron P, Bonduelle C, Pez&#xe9; T, Hurdiel R · Sleep medicine (2026)

Participants: 52
Duration: During a single 170 km ultramarathon race (multiple editions)
Intervention: 20-minute sleep opportunity (nap) vs. remaining awake at checkpoints CP1-CP3
Outcome: Subjective sleepiness (Karolinska Sleepiness Scale, KSS) and reaction time (Psychomotor Vigilance Test, PVT) at checkpoint entry and 1 km post-checkpoint
Effect Size: N/A
Population: 52 completing runners (mean age 43.9 ± 8.3 years) in the 2022, 2023, and 2024 Ultra-Trail du Mont-Blanc

Result: In an observational field study of 52 finishers of the Ultra-Trail du Mont-Blanc (170 km, ~10,000 m elevation gain), 20-minute naps produced immediate reductions in subjective sleepiness (Karolinska Sleepiness Scale) 1 km post-checkpoint, while cognitive benefits (Psychomotor Vigilance Test reaction times) appeared more gradually, with significantly faster reaction times at subsequent checkpoints. Naps served as an effective reactive strategy to reduce perceived drowsiness and partially protect against late-race performance decline without compromising overall race completion times.

Study 6. Cohort profile: Walking for harm reduction through street engagement (WHiSE 2.0).

observational

Verma G, Aden M, Hartman M, Walker JD, Pelland K, Mushquash C, Persaud S, Young M, Gauvin H, Benoit AC · PloS one (2026)

Participants: 356
Duration: Cross-sectional baseline data (prospective cohort ongoing)
Intervention: Community-based, culturally grounded cohort study with interviewer-administered questionnaire (no experimental intervention)
Outcome: Substance use patterns, harm reduction knowledge, HIV/hepatitis C testing uptake, cultural engagement, precarious sleeping situations
Effect Size: N/A
Population: Indigenous people who use drugs in Thunder Bay, Sudbury, and Sault Ste. Marie, Canada (n=356)

Result: Among 356 Indigenous participants across three northern Ontario cities, 39.0% slept on the street, 28.3% in shelters, and 92.1% smoked drugs. Despite high substance use, 84.0% knew what harm reduction was, 82.3% had HIV testing, and 71.3% engaged in cultural ceremonies, with 22.2% reporting cultural teachings affected their harm reduction practices.

Study 7. A Comparison of Nurse-Driven and Combined Physician and Nurse-Driven Interventions for Improving Sleep Quality and Quantity in Hospitalized Patients.

observational

Wong MT, Lo AT, Abdulrahman SD, Sasaki R, Seymann G, Moazzam A · Cureus (2026)

Participants: 92
Duration: 7 months
Intervention: Nightly nurse-led sleep rounds with a personalized Sleep Hygiene Menu (environmental modifications, comfort measures, relaxation aids) with or without physician modification of overnight orders to reduce non-urgent vital signs, labs, and medications during 10 PM-6 AM
Outcome: Subjective sleep quality (modified Richards-Campbell Sleep Questionnaire), sleep latency, nocturnal awakenings, return to sleep, overall sleep quality, patient satisfaction (HCAHPS nighttime quietness score), sitter hours, cost savings
Effect Size: N/A (p values reported but no effect size given)
Population: Medical-surgical inpatients (29 control, 31 nurse intervention, 32 nurse+physician intervention)

Result: This study compared nurse-driven and combined nurse-physician sleep interventions against standard care in 92 medical-surgical inpatients. Both intervention groups reported significantly deeper sleep, shorter sleep latency, fewer awakenings, faster return to sleep, and better overall sleep quality compared to controls (all p < 0.05). The nurse-driven intervention also led to an 8.47% increase in patient satisfaction with nighttime quietness and $21,351.68 in cost savings from reduced sitter hours.

Study 8. Alterations in resting-state control energy of limbic-to-subcortical networks in individuals with alcohol use disorder and comorbid sleep disturbances.

observational

Zeng N, Ding M, Wang M, Hu Q · Addictive behaviors (2026)

Participants: 184
Duration: N/A
Intervention: Observational analysis of resting-state fMRI and sleep quality (PSQI) in AUD vs. healthy controls
Outcome: Static inter-network transition energy (limbic-to-subcortical), PSQI score
Effect Size: N/A
Population: 93 individuals with alcohol use disorder and 91 demographically matched healthy controls from the Human Connectome Project

Result: In individuals with alcohol use disorder (AUD) and comorbid sleep disturbances, the energetic cost of transitions from limbic to subcortical brain networks is altered compared to healthy controls. A significant Group × PSQI interaction (Bonferroni-corrected p = 0.020) showed that in healthy controls, poorer sleep was linked to lower transition energy, but this coupling was absent in AUD. Eleven specific ROI pairs, including parahippocampal, amygdalar, and temporal regions to thalamic subnuclei, survived correction.

Study 9. Sleep Disorders: Management by Alternative Therapies.

observational

Guruswamy Pandian AP, Natarajan A, Mathai B, Gupta S · The Medical clinics of North America (2026)

Participants: N/A
Duration: N/A
Intervention: Alternative therapies including mindfulness, meditation, yoga, relaxation techniques, music therapy, herbal supplements, aromatherapy, and hypnosis
Outcome: Management of sleep disorders (improvement in sleep quality, reduction in sleep disturbances)
Effect Size: N/A
Population: Individuals with sleep disorders (general population with sleep complaints)

Result: The review indicates that complementary and alternative medicine approaches have gained attention for managing sleep disturbances, particularly when conventional treatments are limited by side effects, accessibility, or patient preference. No specific quantitative results are provided in the abstract.

Study 10. Mood States Across a Competitive Season in Collegiate Female Rowers: A Prospective Observational Analysis.

observational

Dziugyte R, Sogard AS, Cobb EA, Raglin JS, Mickleborough TD · International journal of exercise science (2026)

Participants: N/A
Duration: Spring competitive season (exact weeks not specified in abstract)
Intervention: Longitudinal monitoring across a competitive spring rowing season (no specific intervention)
Outcome: Sleep quality (measured via self-report), sleep quantity, mood states (POMS subscales), perceived exertion (RPE), training distance
Effect Size: Small-to-moderate (exact values not reported in abstract)
Population: Collegiate female rowers (12 athletes)

Result:

Mechanism Graph

Intervention
Biological pathway
Sleep regulation
Outcome improvement

Limitations

  • Sample size may be limited
  • Single study — more research needed
  • Population specificity may limit generalizability

Frequently Asked Questions

Does this intervention improve sleep?

Based on this OBSERVATIONAL study published in Clinical psychology &amp; psychotherapy, there is evidence suggesting effects on sleep outcomes. See the full study for details.

What is the recommended dose?

Dose information varies by study. Refer to the original publication for specific dosing details.

Is this evidence reliable?

This is a OBSERVATIONAL study. More research may be needed to confirm findings.

Products

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References

  1. 1.Huyen Trang HN, Vy HT, Cam Van NN, Hong Anh VT, Kieu Nga PT, Hoa HN, Kim Thao VT, Thanh Truc NT, Bang HT. "Sleep quality after endovenous ablation with concomitant phlebectomy in patients with chronic venous disease: A prospective observational study in Vietnam.." Journal of vascular surgery cases and innovative techniques, 2026. PMID: 42494507 DOI: 10.1016/j.jvscit.2026.102358
  2. 2.Yuan N, Avidan AY. "Diagnostic Tools in Sleep Medicine.." The Medical clinics of North America, 2026. PMID: 42498433 DOI: 10.1016/j.mcna.2026.01.012
  3. 3.Yuan L, Kulachai P, Wu QM, Zhang YX, Niu XY, Liang JT, Zheng H. "Sleep disturbances in tension-type headache: a systematic review and meta-analysis.." Journal of neurology, 2026. PMID: 42493638 DOI: 10.1007/s00415-026-14011-9
  4. 4.Almulla AA, Khasawneh MAS. "Exploring the Prevalence and Key Predictors of Probable Depression Among Parents and Primary Caregivers of Children and Adolescents With Specific Learning Disorders in the Kingdom of Saudi Arabia: A Cross-Sectional Explainable Machine-Learning Study.." Clinical psychology &amp; psychotherapy, 2026. PMID: 42490731 DOI: 10.1002/cpp.70310
  5. 5.Bourlois V, Boulagnon A, Elsworth-Edelsten C, Ceugniez M, Claeyssen C, Smith M, Comont L, Clergue J, Baron P, Bonduelle C, Pez&#xe9; T, Hurdiel R. "Do power naps save sleepiness? Cognitive benefits of brief sleep during a 100 miles ultramarathon.." Sleep medicine, 2026. PMID: 42497815 DOI: 10.1016/j.sleep.2026.109159
  6. 6.Verma G, Aden M, Hartman M, Walker JD, Pelland K, Mushquash C, Persaud S, Young M, Gauvin H, Benoit AC. "Cohort profile: Walking for harm reduction through street engagement (WHiSE 2.0).." PloS one, 2026. PMID: 42497183 DOI: 10.1371/journal.pone.0354477
  7. 7.Wong MT, Lo AT, Abdulrahman SD, Sasaki R, Seymann G, Moazzam A. "A Comparison of Nurse-Driven and Combined Physician and Nurse-Driven Interventions for Improving Sleep Quality and Quantity in Hospitalized Patients.." Cureus, 2026. PMID: 42500757 DOI: 10.7759/cureus.111395
  8. 8.Zeng N, Ding M, Wang M, Hu Q. "Alterations in resting-state control energy of limbic-to-subcortical networks in individuals with alcohol use disorder and comorbid sleep disturbances.." Addictive behaviors, 2026. PMID: 42497733 DOI: 10.1016/j.addbeh.2026.108802
  9. 9.Guruswamy Pandian AP, Natarajan A, Mathai B, Gupta S. "Sleep Disorders: Management by Alternative Therapies.." The Medical clinics of North America, 2026. PMID: 42498436 DOI: 10.1016/j.mcna.2026.01.013
  10. 10.Dziugyte R, Sogard AS, Cobb EA, Raglin JS, Mickleborough TD. "Mood States Across a Competitive Season in Collegiate Female Rowers: A Prospective Observational Analysis.." International journal of exercise science, 2026. PMID: 42499687 DOI: 10.1249/00005768-199012000-00018
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.