Supplements

Standardized lime peel supplement (SLPS) improves sleep quality in adults with sleep disturbance

In a randomized, double-blind, placebo-controlled trial, 80 adults with sleep disturbances received either 300 mg/day of SLPS or placebo for 2 weeks. SLPS significantly improved polysomnographic outcomes including reduced sleep latency, wake after sleep onset, and total wake time, as well as enhanced sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness measured by the Epworth Sleepiness Scale was also decreased, with no serious adverse effects reported.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.

observational

Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S · Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)

Participants: N/A
Duration: 2 weeks
Intervention: 300 mg/day standardized lime peel supplement (SLPS) for 2 weeks
Outcome: Polysomnographic measures (sleep latency, wake after sleep onset, total wake time, sleep efficiency, total sleep time, stage 2 sleep) and daytime sleepiness (Epworth Sleepiness Scale)
Effect Size: N/A
Population: Adults with sleep disturbances (80 subjects)

Result:

PubMed: 39970858DOI: 10.1016/j.phymed.2025.156510

Mechanism Graph

SLPS activates GABAA receptors (based on prior mouse study)
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Induces non-rapid eye movement sleep
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Shortens sleep latency
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Result: Improved sleep quality and reduced daytime sleepiness

Limitations

  • ⚠Short intervention period of only 2 weeks
  • ⚠Small sample size of 80 subjects
  • ⚠Mechanism of action inferred from animal study, not directly tested in humans

Frequently Asked Questions

What is standardized lime peel supplement (SLPS)?▼

SLPS is a supplement derived from citrus peels, rich in flavonoids, that has shown sedative-hypnotic effects in animal studies and is being tested for sleep improvement in humans.

How was sleep measured in this study?▼

Sleep was measured using polysomnography, which objectively records brain waves, eye movements, and other physiological signals during sleep, along with the Epworth Sleepiness Scale for daytime sleepiness.

What were the main benefits of SLPS for sleep?▼

SLPS reduced sleep latency (time to fall asleep), wake after sleep onset, and total wake time, while increasing sleep efficiency, total sleep time, and stage 2 sleep.

Were there any side effects of SLPS?▼

No serious adverse effects or side effects were reported among participants in the SLPS group during the 2-week intervention period.

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References

  1. 1.Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S. "Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.." Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025. PMID: 39970858 DOI: 10.1016/j.phymed.2025.156510
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.