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The ALMA multidimensional group intervention improves cognitive function in women with breast cancer undergoing active oncological treatment.

This protocol describes a randomized controlled trial evaluating the ALMA intervention (two 120 min face-to-face sessions/week for four months) in 63 women with breast cancer. The primary outcome is objective global cognitive performance measured by the Montreal Cognitive Assessment, with secondary outcomes including perceived cognitive function, sleep quality, and functional autonomy.

Last updated: Jul 17, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effectiveness of the ALMA Intervention on Cognitive Function in Women with Breast Cancer: Protocol for a Randomized Controlled Trial.

observational

Teixeira de Sousa SR, Sánchez-Rodríguez JL, Sánchez-Gil A, Sánchez-Gómez C, Arroyo-Garrapucho N, Fonseca-Sánchez E, Figuero-Pérez L, Sánchez-González JL, Fernández-Rodríguez EJ · Journal of clinical medicine (2026)

Participants: N/A
Duration: 4 months
Intervention: ALMA multidimensional group intervention combining psychoeducation, targeted cognitive stimulation, and group feedback (two 120 min sessions/week for four months)
Outcome: Objective global cognitive performance (Montreal Cognitive Assessment), perceived cognitive function, everyday cognition, functional autonomy, anxiety, sleep quality, performance status, and everyday memory failures
Effect Size: N/A
Population: Women with breast cancer undergoing active oncological treatment

Result:

PubMed: 42452339DOI: 10.3390/jcm15134876

Mechanism Graph

Psychoeducation addresses cognitive concerns and coping strategies
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Targeted cognitive stimulation exercises specific cognitive domains
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Group feedback provides social support and reinforcement
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Result: Improved cognitive function and related outcomes

Limitations

  • ⚠Single-centre design may limit generalizability
  • ⚠Results are expected and not yet available; protocol only
  • ⚠Small sample size (n=63) may reduce statistical power

Frequently Asked Questions

What is the ALMA intervention?▼

ALMA stands for Playful Attention and Active Memory, a multidimensional group intervention combining psychoeducation, cognitive stimulation, and group feedback delivered in two 120-minute sessions per week for four months.

Who is eligible for this study?▼

Women with breast cancer currently undergoing active oncological treatment at the University Healthcare Complex of Salamanca, Spain.

What is the primary outcome measured?▼

The primary outcome is objective global cognitive performance assessed by the Montreal Cognitive Assessment (MoCA).

How does this trial compare ALMA to other interventions?▼

The trial compares ALMA to a health education control group and an individual non-tailored cognitive training group in a three-arm randomized design.

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References

  1. 1.Teixeira de Sousa SR, Sánchez-Rodríguez JL, Sánchez-Gil A, Sánchez-Gómez C, Arroyo-Garrapucho N, Fonseca-Sánchez E, Figuero-Pérez L, Sánchez-González JL, Fernández-Rodríguez EJ. "Effectiveness of the ALMA Intervention on Cognitive Function in Women with Breast Cancer: Protocol for a Randomized Controlled Trial.." Journal of clinical medicine, 2026. PMID: 42452339 DOI: 10.3390/jcm15134876
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.