Amino AcidsL-Theanine
Theanine alleviates sleep disturbances and depression induced by sleep deprivation through neuroinflammation reduction
Theanine, a phytochemical from Camellia sinensis, exerts therapeutic effects on mental disorders caused by cumulative stress, including mild sleep disturbances and depression induced by sleep deprivation. The neuroprotective mechanism involves alleviating neuroinflammation. The paper reviews literature from the past 5 years.
Evidence Score
Evidence Score32/100
Human RCT
Meta-analysis
Mechanism
Safety
Confidencelow
Study Evidence
Study 1. Theanine: a phytochemical candidate for neural protection.
observationalQiang Y, Luo Q, Zhang J, Ming C, Chong X, Huang F, Gui A, Wang J, Yin H, Ahmad MZ, He HF · Journal of the science of food and agriculture (2026)
Participants: N/A
Duration: N/A
Intervention: Theanine (from Camellia sinensis)
Outcome: Sleep disturbances, mental disorders (including depression induced by sleep deprivation)
Effect Size: N/A
Population: Individuals with cumulative stress (including mild sleep disturbances and sleep deprivation)
Result:
Mechanism Graph
Alleviation of neuroinflammation
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Reduction of oxidative stress-induced ferroptosis in neuronal cells
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Modulation of neural stem cell differentiation and development
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Therapeutic effects on sleep disturbances and depression
Limitations
- ⚠Abstract does not specify sample sizes or effect sizes from individual studies
- ⚠No direct human RCT data provided in the abstract; mechanisms are primarily from preclinical studies
- ⚠Further investigations needed for rigorous understanding
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References
- 1.Qiang Y, Luo Q, Zhang J, Ming C, Chong X, Huang F, Gui A, Wang J, Yin H, Ahmad MZ, He HF. "Theanine: a phytochemical candidate for neural protection.." Journal of the science of food and agriculture, 2026. PMID: 42163019 DOI: 10.1002/jsfa.70740
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.