B. subtilis Rosell-179 probiotic supplementation enhances skin carotenoid status in healthy premenopausal women
A 10-week double-blind RCT in 37 premenopausal women found that daily supplementation with a mixed carotenoid supplement plus B. subtilis Rosell-179 probiotic led to a larger increase in skin carotenoid status (SCS) compared to carotenoid supplement plus placebo, with an estimated difference of 1.1 units at week 10 (p=0.056). Plasma carotenoids increased in both groups from baseline to week 5 but did not continue to increase, and no significant changes were observed in antioxidant capacity, inflammation, or skin health markers.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
B. subtilis Rosell-179 probiotic supplementation enhances skin carotenoid status in healthy premenopausal women The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).
The Claim
B. subtilis Rosell-179 probiotic supplementation enhances skin carotenoid status in healthy premenopausal women
This conclusion is most relevant to: 37 healthy premenopausal women (average age 40).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Probiotics for enhanced tissue carotenoid status: A double-blind, randomized controlled trial. (The Journal of nutrition, 2026) —
How It Works
The proposed biological pathway:
- ▸Probiotic B. subtilis Rosell-179 may enhance gut absorption of carotenoids
- ▸Improved carotenoid bioavailability leads to increased skin deposition
- ▸Higher skin carotenoid status reflects improved systemic carotenoid status
- ▸Result: Greater SCS increase in probiotic group vs placebo
Who Might Benefit
Evidence fit by population:
- ▸37 healthy premenopausal women (average age 40)
Recommended Dose
17 mg total carotenoids daily plus probiotic (strain not specified in dose)
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Small sample size (n=37) limits statistical power and generalizability
- ▸p-value of 0.056 does not reach conventional significance threshold of 0.05
- ▸Only premenopausal women studied, limiting applicability to other populations
Frequently Asked Questions
What is skin carotenoid status and why is it important?▼
Skin carotenoid status (SCS) is a non-invasive measure of carotenoid levels in the skin, which serves as a reliable indicator of dietary carotenoid intake and reflects interindividual variability in carotenoid metabolism and absorption.
Did the probiotic significantly improve carotenoid status?▼
The probiotic group showed a larger increase in SCS than placebo by 1.1 units at week 10, but this result was not statistically significant (p=0.056), suggesting a potential trend that requires further study.
What other health markers were measured in this study?▼
Secondary outcomes included plasma carotenoids, markers of antioxidant capacity, inflammation, skin hydration, wrinkling, dietary intake, physical activity, quality of life, and sleep.
Who was eligible for this trial?▼
The study included 37 healthy premenopausal women with an average age of 40 years, who took a mixed carotenoid supplement daily along with either a probiotic or placebo for 10 weeks.
References
- 1.Roldos LG, Iskandar MM, Oula ML, Piano A, Auger J, Tompkins TA, Khouri L, Binda S, Kubow S. “Probiotics for enhanced tissue carotenoid status: A double-blind, randomized controlled trial..” The Journal of nutrition, 2026. PMID: 42431406 DOI: 10.1016/j.tjnut.2026.101716