Both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha) improve sleep quality in individuals with high stress
In a 60-day randomized, double-blind, placebo-controlled trial involving 186 participants with high stress, both VL-G-A57 and VL-G-E12 significantly improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) compared to placebo (VL-G-A57: p=0.0008, VL-G-E12: p<0.0001). Restorative Sleep Questionnaire-Weekly (RSQ-W) results also showed significant improvements in both active groups versus placebo (p<0.0001).
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha) improve sleep quality in individuals with high stress The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha) improve sleep quality in individuals with high stress
This conclusion is most relevant to: Individuals aged 18 to 65 years with high stress and BMI 18-29.9 kg/m².
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study. (Trials, 2026) —
How It Works
The proposed biological pathway:
- ▸Adaptogens modulate HPA axis activity
- ▸Reduction in cortisol and stress response
- ▸Improved regulation of sleep-wake cycle
- ▸Result: Enhanced sleep quality and restorative sleep
Who Might Benefit
Evidence fit by population:
- ▸Individuals aged 18 to 65 years with high stress and BMI 18-29.9 kg/m²
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Dose information not provided in abstract
- ▸Mechanism of action not directly measured in this study
- ▸Short-term duration (60 days) limits long-term conclusions
Frequently Asked Questions
What is VL-G-A57?▼
VL-G-A57 is a plant-based adaptogen formula containing Rhodiola rosea, holy basil (Ocimum sanctum), and Schisandra chinensis.
What is VL-G-E12?▼
VL-G-E12 is a full-spectrum ashwagandha (Withania somnifera) root formula.
How was sleep quality measured in this study?▼
Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and the Restorative Sleep Questionnaire-Weekly (RSQ-W).
Did both formulas improve sleep?▼
Yes, both VL-G-A57 and VL-G-E12 significantly improved sleep quality and restorative sleep compared to placebo at day 60.
References
- 1.McKinney E, Stewart J, Kewalramani R, Singh S. “Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study..” Trials, 2026. PMID: 41656269 DOI: 10.1186/s13063-026-09495-9