BXSMD elevates ESR1 and ESR2 expression in the hypothalamus and hippocampus of CSD female mice
Banxia Shumi Decoction (BXSMD) was found to increase both mRNA and protein expressions of estrogen receptors ESR1 and ESR2 in the hypothalamus and hippocampus of female mice with chronic sleep deprivation. The treatment also improved sleep-wake patterns, increased 5-HT, GABA, and MT levels, and decreased Glu, NE, and DA levels.
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BXSMD elevates ESR1 and ESR2 expression in the hypothalamus and hippocampus of CSD female mice The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
BXSMD elevates ESR1 and ESR2 expression in the hypothalamus and hippocampus of CSD female mice
This conclusion is most relevant to: Female mice with chronic sleep deprivation (CSD) induced by platform water environment for 21 days.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice. (Journal of ethnopharmacology, 2023) —
How It Works
The proposed biological pathway:
- ▸BXSMD contains multiple active compounds (ferulic acid, kaempferol, daidzein, apigenin, berberine, etc.)
- ▸These compounds upregulate mRNA expression of Esr1 and Esr2 in hypothalamus and hippocampus
- ▸Increased ESR1 and ESR2 protein levels activate estrogen signaling pathway
- ▸Result: Regulation of sleep-wake disorder caused by chronic sleep deprivation
Who Might Benefit
Evidence fit by population:
- ▸Female mice with chronic sleep deprivation (CSD) induced by platform water environment for 21 days
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal model (mice) limits direct translation to human chronic insomnia
- ▸Chemical composition of BXSMD was identified but specific active compound(s) responsible for ESR1/ESR2 upregulation were not isolated or tested individually
Frequently Asked Questions
What is BXSMD?▼
Banxia Shumi Decoction (BXSMD) is a traditional Chinese herbal formula used for thousands of years to treat chronic insomnia.
How does BXSMD affect estrogen receptors?▼
BXSMD increases both mRNA and protein expression of estrogen receptors ESR1 and ESR2 in the hypothalamus and hippocampus of sleep-deprived female mice.
What neurotransmitters are changed by BXSMD?▼
BXSMD increases 5-HT, GABA, and melatonin levels, and decreases glutamate, norepinephrine, and dopamine levels in chronic sleep-deprived mice.
Is this study on humans or animals?▼
This study was conducted on female mice with chronic sleep deprivation, not on human subjects.
References
- 1.Wang S, Liu L, Liang S, Yang J, Zhang Y, Liu X. “Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice..” Journal of ethnopharmacology, 2023. PMID: 37517566 DOI: 10.1016/j.jep.2023.116973