Conserved sleep orthologs, including DnaK, SHMT, and potassium channel proteins, are present in Epsilonproteobacteria and show sequence similarities of 39.13% to 61.45%.
Phylogenomic analysis of Sulfurimonas paralvinellae identified conserved sleep-related orthologs such as DnaK (Hsp70), serine hydroxymethyltransferase, and potassium channel family proteins, with sequence similarities ranging from 39.13% to 61.45%. Proteins with fewer domains, like adenylate kinase, showed greater conservation, while bifunctional protein-serine/threonine kinases and phosphatases exhibited adaptations linked to the extremophilic environment. Gene Ontology analysis highlighted catalytic activity, potassium channel function, and cellular processes, emphasizing ion channels in sleep-wake regulation.
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Conserved sleep orthologs, including DnaK, SHMT, and potassium channel proteins, are present in Epsilonproteobacteria and show sequence similarities of 39.13% to 61.45%. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Conserved sleep orthologs, including DnaK, SHMT, and potassium channel proteins, are present in Epsilonproteobacteria and show sequence similarities of 39.13% to 61.45%.
This conclusion is most relevant to: Sulfurimonas paralvinellae (Epsilonproteobacteria class).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: investigating sleep mysteries through phylogenomics. (World journal of microbiology & biotechnology, 2025) —
How It Works
The proposed biological pathway:
- ▸Phylogenomic methods applied to identify sleep-related orthologs in Epsilonproteobacteria
- ▸Conserved orthologs found: DnaK, SHMT, potassium channel proteins (39.13%-61.45% similarity)
- ▸Proteins with fewer domains (e.g., adenylate kinase) showed higher conservation
- ▸Bifunctional kinases/phosphatases adapted to high-pressure/high-temperature conditions
- ▸Gene Ontology analysis linked potassium channels to sleep-wake cycle regulation
Who Might Benefit
Evidence fit by population:
- ▸Sulfurimonas paralvinellae (Epsilonproteobacteria class)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Study is based on computational phylogenomics and sequence analysis, not experimental validation
- ▸Findings are limited to a single extremophilic species (S. paralvinellae), reducing generalizability
- ▸No direct behavioral or physiological sleep measurements were taken
Frequently Asked Questions
What sleep-related genes were found in Epsilonproteobacteria?▼
Conserved orthologs include DnaK (Hsp70), serine hydroxymethyltransferase (SHMT), and potassium channel family proteins.
How similar are these sleep orthologs to known sleep genes?▼
Sequence similarities range from 39.13% to 61.45%.
Why are potassium channels important in this study?▼
Gene Ontology analysis indicated potassium channel function is significant for regulating the sleep-wake cycle.
What is the significance of studying sleep genes in bacteria?▼
It provides an evolutionary perspective on sleep-related genes and their association with metabolic and environmental changes.
References
- 1.Pandi-Perumal SR, Saravanan KM, Paul S, Warren Spence D, Chidambaram SB. “Studying sleep orthologs in Epsilonproteobacteria through an evolutionary lens: investigating sleep mysteries through phylogenomics..” World journal of microbiology & biotechnology, 2025. PMID: 40289222 DOI: 10.1007/s11274-025-04361-3