Dietary apigenin intake positively correlates with sleep quality in a large cohort of adults
A large cohort study found that higher dietary intake of apigenin, a natural flavonoid found in chamomile and other plants, is associated with better sleep quality in adults. This supports apigenin's potential role in improving sleep, though the abstract does not provide specific correlation coefficients or effect sizes.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Dietary apigenin intake positively correlates with sleep quality in a large cohort of adults The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Dietary apigenin intake positively correlates with sleep quality in a large cohort of adults
This conclusion is most relevant to: Large cohort of adults.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Apigenin: a natural molecule at the intersection of sleep and aging. (Frontiers in nutrition, 2024) —
How It Works
The proposed biological pathway:
- ▸Apigenin inhibits CD38, increasing NAD+ levels
- ▸NAD+ decline with age is linked to sleep and aging dysregulation
- ▸Apigenin modulates GABA and inflammatory pathways
- ▸Result: Improved sleep quality and potential longevity benefits
Who Might Benefit
Evidence fit by population:
- ▸Large cohort of adults
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Correlational study design cannot establish causality
- ▸Specific effect size and statistical details not provided in abstract
- ▸Confounding factors (e.g., overall diet, lifestyle) not controlled in the cohort analysis
Frequently Asked Questions
What is apigenin and where is it found?▼
Apigenin is a natural flavonoid found in chamomile, parsley, celery, and other plants. It is known for its antioxidant and anti-inflammatory properties.
How does apigenin affect sleep?▼
Apigenin may improve sleep quality by inhibiting CD38 (boosting NAD+ levels) and modulating GABA receptors, which have sedative effects. Human studies with chamomile extract and dietary apigenin intake support these benefits.
Is apigenin safe for long-term use?▼
Apigenin from dietary sources is generally safe. However, high-dose supplements may have unknown risks, and more clinical studies are needed to confirm long-term safety.
Does apigenin have anti-aging effects?▼
Animal studies suggest apigenin extends lifespan in worms and flies, improves learning and memory in older mice, and reduces tumor growth. These effects are linked to NAD+ elevation and anti-inflammatory mechanisms.
References
- 1.Kramer DJ, Johnson AA. “Apigenin: a natural molecule at the intersection of sleep and aging..” Frontiers in nutrition, 2024. PMID: 38476603 DOI: 10.3389/fnut.2024.1359176