FlavonoidsApigenin

Dietary apigenin intake positively correlates with sleep quality in a large cohort of adults

A large cohort study found that higher dietary intake of apigenin, a natural flavonoid found in chamomile and other plants, is associated with better sleep quality in adults. This supports apigenin's potential role in improving sleep, though the abstract does not provide specific correlation coefficients or effect sizes.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Apigenin: a natural molecule at the intersection of sleep and aging.

observational

Kramer DJ, Johnson AA · Frontiers in nutrition (2024)

Participants: N/A
Duration: N/A
Intervention: Dietary apigenin intake (from food sources)
Outcome: Sleep quality (measured via self-report or validated scale, not specified in abstract)
Effect Size: N/A
Population: Large cohort of adults

Result:

PubMed: 38476603DOI: 10.3389/fnut.2024.1359176

Mechanism Graph

Apigenin inhibits CD38, increasing NAD+ levels
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NAD+ decline with age is linked to sleep and aging dysregulation
↓
Apigenin modulates GABA and inflammatory pathways
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Result: Improved sleep quality and potential longevity benefits

Limitations

  • ⚠Correlational study design cannot establish causality
  • ⚠Specific effect size and statistical details not provided in abstract
  • ⚠Confounding factors (e.g., overall diet, lifestyle) not controlled in the cohort analysis

Frequently Asked Questions

What is apigenin and where is it found?▼

Apigenin is a natural flavonoid found in chamomile, parsley, celery, and other plants. It is known for its antioxidant and anti-inflammatory properties.

How does apigenin affect sleep?▼

Apigenin may improve sleep quality by inhibiting CD38 (boosting NAD+ levels) and modulating GABA receptors, which have sedative effects. Human studies with chamomile extract and dietary apigenin intake support these benefits.

Is apigenin safe for long-term use?▼

Apigenin from dietary sources is generally safe. However, high-dose supplements may have unknown risks, and more clinical studies are needed to confirm long-term safety.

Does apigenin have anti-aging effects?▼

Animal studies suggest apigenin extends lifespan in worms and flies, improves learning and memory in older mice, and reduces tumor growth. These effects are linked to NAD+ elevation and anti-inflammatory mechanisms.

Products

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References

  1. 1.Kramer DJ, Johnson AA. "Apigenin: a natural molecule at the intersection of sleep and aging.." Frontiers in nutrition, 2024. PMID: 38476603 DOI: 10.3389/fnut.2024.1359176
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.