Exogenous melatonin exhibits both therapeutic benefits and potential toxicological concerns, particularly in specific populations
This review explores melatonin's dual role as a therapeutic agent for conditions like insomnia and gastrointestinal disorders, while highlighting emerging toxicological concerns. The paper emphasizes the need for further studies to balance therapeutic benefits with safety, especially in susceptible groups.
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Exogenous melatonin exhibits both therapeutic benefits and potential toxicological concerns, particularly in specific populations The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Exogenous melatonin exhibits both therapeutic benefits and potential toxicological concerns, particularly in specific populations
This conclusion is most relevant to: General population, with specific attention to susceptible groups (e.g., children, elderly, pregnant women).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Melatonin's paradox: From therapeutic benefits to toxicity warnings. (Chemico-biological interactions, 2025) —
How It Works
The proposed biological pathway:
- ▸Melatonin binds to MT1/MT2 receptors
- ▸Regulates circadian rhythms and sleep-wake cycle
- ▸Exhibits anti-oxidative, anti-inflammatory, and immunomodulatory effects
- ▸Potential toxicity mechanisms in susceptible populations
Who Might Benefit
Evidence fit by population:
- ▸General population, with specific attention to susceptible groups (e.g., children, elderly, pregnant women)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Abstract does not provide specific quantitative data or effect sizes
- ▸No detailed information on specific toxicological mechanisms or safety thresholds
Frequently Asked Questions
What are the therapeutic benefits of exogenous melatonin?▼
Exogenous melatonin is used as a supplement for insomnia, circadian rhythm disorders, and gastrointestinal issues, and has anti-oxidative and anti-inflammatory properties.
Who is at risk for toxic effects from melatonin?▼
Specific populations such as children, elderly individuals, and those with certain health conditions may be more susceptible to toxicological concerns from exogenous melatonin.
What is the main paradox discussed in this paper?▼
The paradox is that melatonin has well-documented therapeutic benefits but also emerging evidence of potential toxicity, especially in vulnerable groups.
What mechanisms underlie melatonin's therapeutic effects?▼
Melatonin acts through anti-oxidative reduction, anti-inflammatory pathways, and immunomodulation, in addition to regulating sleep and circadian rhythms.
References
- 1.Amrollahi-Sharifabadi M, Oladejo TO, Ibrahim AS, Shakoor B, Mehrpour O, Sadeghi-Hashjin G, Gonçalves S. “Melatonin's paradox: From therapeutic benefits to toxicity warnings..” Chemico-biological interactions, 2025. PMID: 40383469 DOI: 10.1016/j.cbi.2025.111556