HormonesMelatonin

Exogenous melatonin exhibits both therapeutic benefits and potential toxicological concerns, particularly in specific populations

This review explores melatonin's dual role as a therapeutic agent for conditions like insomnia and gastrointestinal disorders, while highlighting emerging toxicological concerns. The paper emphasizes the need for further studies to balance therapeutic benefits with safety, especially in susceptible groups.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Melatonin's paradox: From therapeutic benefits to toxicity warnings.

observational

Amrollahi-Sharifabadi M, Oladejo TO, Ibrahim AS, Shakoor B, Mehrpour O, Sadeghi-Hashjin G, Gonçalves S · Chemico-biological interactions (2025)

Participants: N/A
Duration: N/A
Intervention: Exogenous melatonin supplementation
Outcome: Therapeutic benefits (sleep regulation, anti-inflammatory effects) and toxicological effects (safety concerns in specific populations)
Effect Size: N/A
Population: General population, with specific attention to susceptible groups (e.g., children, elderly, pregnant women)

Result:

PubMed: 40383469DOI: 10.1016/j.cbi.2025.111556

Mechanism Graph

Melatonin binds to MT1/MT2 receptors
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Regulates circadian rhythms and sleep-wake cycle
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Exhibits anti-oxidative, anti-inflammatory, and immunomodulatory effects
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Potential toxicity mechanisms in susceptible populations

Limitations

  • ⚠Abstract does not provide specific quantitative data or effect sizes
  • ⚠No detailed information on specific toxicological mechanisms or safety thresholds

Frequently Asked Questions

What are the therapeutic benefits of exogenous melatonin?▼

Exogenous melatonin is used as a supplement for insomnia, circadian rhythm disorders, and gastrointestinal issues, and has anti-oxidative and anti-inflammatory properties.

Who is at risk for toxic effects from melatonin?▼

Specific populations such as children, elderly individuals, and those with certain health conditions may be more susceptible to toxicological concerns from exogenous melatonin.

What is the main paradox discussed in this paper?▼

The paradox is that melatonin has well-documented therapeutic benefits but also emerging evidence of potential toxicity, especially in vulnerable groups.

What mechanisms underlie melatonin's therapeutic effects?▼

Melatonin acts through anti-oxidative reduction, anti-inflammatory pathways, and immunomodulation, in addition to regulating sleep and circadian rhythms.

Products

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References

  1. 1.Amrollahi-Sharifabadi M, Oladejo TO, Ibrahim AS, Shakoor B, Mehrpour O, Sadeghi-Hashjin G, Gonçalves S. "Melatonin's paradox: From therapeutic benefits to toxicity warnings.." Chemico-biological interactions, 2025. PMID: 40383469 DOI: 10.1016/j.cbi.2025.111556
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.