Supplements

Flavonoids inhibit MCT1-mediated transport of GHB, reducing sleep time in rats

In vitro, flavonoids such as luteolin, morin, and phloretin inhibited MCT1-mediated uptake of GHB in rat MCT1-transfected cells, with IC50 values of 0.41, 6.41, and 2.57 μM, respectively. In rats, intravenous luteolin (10 mg/kg) increased renal and total clearance of GHB and significantly decreased sleep time from 165 ± 10 min to 121 ± 5 min after a 1000 mg/kg GHB dose.

1 min read•Updated Jul 7, 2026•0 RCTs•View structured evidence →
Evidence Score26/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism☆☆☆☆☆
Safety☆☆☆☆☆
Confidencelow

This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.

Flavonoids inhibit MCT1-mediated transport of GHB, reducing sleep time in rats The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 26/100 (low).

The Claim

Flavonoids inhibit MCT1-mediated transport of GHB, reducing sleep time in rats

This conclusion is most relevant to: Rats (in vivo); rat MCT1-transfected MDA-MB231 cells (in vitro).

What the Research Shows

The conclusion draws on 1 linked study. Highlights from the cited literature:

  • ▸Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. (Drug metabolism and disposition: the biological fate of chemicals, 2007) —

How It Works

The proposed biological pathway:

  • ▸Flavonoids bind to MCT1 transporter
  • ▸Competitive inhibition of GHB uptake at MCT1
  • ▸Reduced renal reabsorption of GHB
  • ▸Increased GHB clearance and decreased sleep time

Who Might Benefit

Evidence fit by population:

  • ▸Rats (in vivo); rat MCT1-transfected MDA-MB231 cells (in vitro)

Limitations & Caveats

Important context when interpreting this evidence:

  • ▸Animal model (rats) may not directly translate to human physiology
  • ▸Only one flavonoid (luteolin) tested in vivo; effects of other flavonoids not confirmed in living animals

References

  1. 1.Wang Q, Morris ME. “Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo..” Drug metabolism and disposition: the biological fate of chemicals, 2007. PMID: 17108059 DOI: 10.1124/dmd.106.012369
Disclaimer: This article is auto-generated from structured research data for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.