Supplements

Hericium erinaceus supplementation improves symptoms of sleep disorders

A systematic review of five RCTs and three pilot clinical trials found that Hericium erinaceus (Lion's Mane mushroom) reduced symptoms of sleep disorders. The review also reported cognitive improvements, with a combined weighted mean increase of 1.17 on the Mini-Mental State Examination in intervention groups.

1 min read•Updated Jul 7, 2026•0 RCTs•View structured evidence →
Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism☆☆☆☆☆
Safety☆☆☆☆☆
Confidencelow

This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.

Hericium erinaceus supplementation improves symptoms of sleep disorders The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 34/100 (low).

The Claim

Hericium erinaceus supplementation improves symptoms of sleep disorders

This conclusion is most relevant to: Participants with and without dementia, including those with mood dysregulation.

What the Research Shows

The conclusion draws on 1 linked study. Highlights from the cited literature:

  • ▸Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review. (Frontiers in nutrition, 2025) —

How It Works

The proposed biological pathway:

  • ▸HE enhances pro-BDNF and BDNF production
  • ▸Promotes hippocampal neurogenesis
  • ▸Improves behavior and mood regulation
  • ▸Reduces symptoms of sleep disorders

Who Might Benefit

Evidence fit by population:

  • ▸Participants with and without dementia, including those with mood dysregulation

Limitations & Caveats

Important context when interpreting this evidence:

  • ▸Only one systematic review with limited number of RCTs (5) and pilot trials (3) specifically addressing sleep outcomes
  • ▸Potential side effects (stomach discomfort, headache, allergic reactions) were commonly unreported, limiting safety assessment

References

  1. 1.Menon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R. “Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review..” Frontiers in nutrition, 2025. PMID: 40959699 DOI: 10.3389/fnut.2025.1641246
Disclaimer: This article is auto-generated from structured research data for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.