Supplements
Hericium erinaceus supplementation improves symptoms of sleep disorders
A systematic review of five RCTs and three pilot clinical trials found that Hericium erinaceus (Lion's Mane mushroom) reduced symptoms of sleep disorders. The review also reported cognitive improvements, with a combined weighted mean increase of 1.17 on the Mini-Mental State Examination in intervention groups.
Evidence Score
Evidence Score34/100
Human RCT
Meta-analysis
Mechanism
Safety
Confidencelow
Study Evidence
Study 1. Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.
observationalMenon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R · Frontiers in nutrition (2025)
Participants: N/A
Duration: N/A
Intervention: Hericium erinaceus supplementation (various forms, including mycelium extracts)
Outcome: Symptoms of sleep disorders
Effect Size: N/A
Population: Participants with and without dementia, as well as animal models
Result:
Mechanism Graph
HE enhances pro-BDNF and BDNF production
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Promotes hippocampal neurogenesis
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Improves behavior and mood regulation
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Reduces symptoms of sleep disorders
Limitations
- ⚠Only one systematic review with limited number of RCTs (5) and pilot trials (3) specifically addressing sleep outcomes
- ⚠Potential side effects (stomach discomfort, headache, allergic reactions) were commonly unreported, limiting safety assessment
Products
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References
- 1.Menon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R. "Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.." Frontiers in nutrition, 2025. PMID: 40959699 DOI: 10.3389/fnut.2025.1641246
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.