Higher magnesium depletion score is associated with increased risk of circadian syndrome, partially mediated by body mass index
In a cross-sectional study of 12,328 U.S. adults from NHANES 2005-2018, higher magnesium depletion score (MDS) was significantly associated with increased risk of circadian syndrome (OR = 1.193, 95% CI: 1.099-1.295, P < 0.001). Body mass index mediated 21% (95% CI: 12.98-34%) of this association.
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Higher magnesium depletion score is associated with increased risk of circadian syndrome, partially mediated by body mass index The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 34/100 (low).
The Claim
Higher magnesium depletion score is associated with increased risk of circadian syndrome, partially mediated by body mass index
This conclusion is most relevant to: 12,328 participants from the U.S. National Health and Nutrition Examination Survey (NHANES) 2005-2018.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Magnesium depletion score and circadian syndrome: Mediated by body mass index. (Science progress, 2026) —
How It Works
The proposed biological pathway:
- ▸Higher MDS indicates greater magnesium deficiency
- ▸Magnesium deficiency may disrupt metabolic and neurological processes
- ▸BMI partially mediates the association between MDS and CircS
- ▸Result: Higher MDS linked to increased CircS risk
Who Might Benefit
Evidence fit by population:
- ▸12,328 participants from the U.S. National Health and Nutrition Examination Survey (NHANES) 2005-2018
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Cross-sectional design prevents causal inference
- ▸MDS is an indirect biomarker, not direct serum magnesium measurement
- ▸CircS is a newly defined syndrome with limited validation
Frequently Asked Questions
What is magnesium depletion score (MDS)?▼
MDS is a composite biomarker calculated from diuretic or proton pump inhibitor use, estimated glomerular filtration rate, and alcohol consumption, used to estimate magnesium deficiency.
What is circadian syndrome?▼
Circadian syndrome is a recently defined condition that includes metabolic syndrome components, depressive symptoms, and short sleep duration, reflecting disruptions in circadian rhythms.
How does BMI mediate the link between magnesium and circadian syndrome?▼
The study found that BMI explains about 21% of the association between MDS and CircS, suggesting that magnesium deficiency may influence body weight, which in turn affects circadian health.
Is this study applicable to non-U.S. populations?▼
The study used a nationally representative U.S. sample, so generalizability to other populations may be limited without further validation.
References
- 1.Wang Y, Wu J, Zhang Y, Yu P, Wen G, Li K, Zhang X, Xiang R, Zheng Z. “Magnesium depletion score and circadian syndrome: Mediated by body mass index..” Science progress, 2026. PMID: 42132340 DOI: 10.1177/00368504261451366