Lactiplantibacillus plantarum SY1 extends lifespan and delays paralysis in C. elegans, suggesting neuroprotective and anti-aging effects
In vivo experiments showed that L. plantarum SY1 extended the lifespan of C. elegans N2, enhanced oxidative stress resistance, and delayed paralysis in transgenic C. elegans (CL4176) by 23.53%. The strain also demonstrated significant antioxidant capacity, including 49±0.2% DPPH radical scavenging rate and 86.1±0.14% hydroxyl radical scavenging rate.
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Lactiplantibacillus plantarum SY1 extends lifespan and delays paralysis in C. elegans, suggesting neuroprotective and anti-aging effects The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 26/100 (low).
The Claim
Lactiplantibacillus plantarum SY1 extends lifespan and delays paralysis in C. elegans, suggesting neuroprotective and anti-aging effects
This conclusion is most relevant to: Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production. (BMC microbiology, 2025) —
How It Works
The proposed biological pathway:
- ▸GABA production by L. plantarum SY1
- ▸Antioxidant activity (DPPH, hydroxyl, superoxide radical scavenging)
- ▸Enhanced oxidative stress resistance in C. elegans
- ▸Delayed paralysis and extended lifespan
Who Might Benefit
Evidence fit by population:
- ▸Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Study conducted in C. elegans model, not in humans or mammals
- ▸GABA production optimized in vitro (1.49 g/L) but in vivo GABA levels not directly measured
Frequently Asked Questions
What is the main benefit of Lactiplantibacillus plantarum SY1?▼
It produces GABA, an inhibitory neurotransmitter, and shows antioxidant and neuroprotective effects, extending lifespan and delaying paralysis in C. elegans.
How much GABA did the optimized strain produce?▼
Under optimal conditions (37°C, pH 4.44, 96 h fermentation, 4.16% inoculum), GABA production reached 1.49 g/L.
Is this study done in humans?▼
No, the in vivo experiments were performed in Caenorhabditis elegans, a nematode model, not in humans.
What antioxidant activities were measured?▼
The strain showed 49±0.2% DPPH radical scavenging, 86.1±0.14% hydroxyl radical scavenging, and 32.7±1.6% superoxide radical anion scavenging rates.
References
- 1.Bai X, Shi P, Chu W. “Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production..” BMC microbiology, 2025. PMID: 40442580 DOI: 10.1186/s12866-025-04070-9