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Lactiplantibacillus plantarum SY1 extends lifespan and delays paralysis in C. elegans, suggesting neuroprotective and anti-aging effects

In vivo experiments showed that L. plantarum SY1 extended the lifespan of C. elegans N2, enhanced oxidative stress resistance, and delayed paralysis in transgenic C. elegans (CL4176) by 23.53%. The strain also demonstrated significant antioxidant capacity, including 49±0.2% DPPH radical scavenging rate and 86.1±0.14% hydroxyl radical scavenging rate.

Last updated: Aug 25, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score26/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production.

observational

Bai X, Shi P, Chu W · BMC microbiology (2025)

Participants: N/A
Duration: Not specified in abstract
Intervention: Oral administration of GABA-producing Lactiplantibacillus plantarum SY1
Outcome: Lifespan extension, oxidative stress resistance, paralysis delay (23.53%)
Effect Size: 23.53% delay in paralysis
Population: Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176

Result:

PubMed: 40442580DOI: 10.1186/s12866-025-04070-9

Mechanism Graph

GABA production by L. plantarum SY1
↓
Antioxidant activity (DPPH, hydroxyl, superoxide radical scavenging)
↓
Enhanced oxidative stress resistance in C. elegans
↓
Delayed paralysis and extended lifespan

Limitations

  • ⚠Study conducted in C. elegans model, not in humans or mammals
  • ⚠GABA production optimized in vitro (1.49 g/L) but in vivo GABA levels not directly measured

Frequently Asked Questions

What is the main benefit of Lactiplantibacillus plantarum SY1?▼

It produces GABA, an inhibitory neurotransmitter, and shows antioxidant and neuroprotective effects, extending lifespan and delaying paralysis in C. elegans.

How much GABA did the optimized strain produce?▼

Under optimal conditions (37°C, pH 4.44, 96 h fermentation, 4.16% inoculum), GABA production reached 1.49 g/L.

Is this study done in humans?▼

No, the in vivo experiments were performed in Caenorhabditis elegans, a nematode model, not in humans.

What antioxidant activities were measured?▼

The strain showed 49±0.2% DPPH radical scavenging, 86.1±0.14% hydroxyl radical scavenging, and 32.7±1.6% superoxide radical anion scavenging rates.

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References

  1. 1.Bai X, Shi P, Chu W. "Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production.." BMC microbiology, 2025. PMID: 40442580 DOI: 10.1186/s12866-025-04070-9
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.