Lactiplantibacillus plantarum SY1 extends lifespan, enhances oxidative stress resistance, and delays paralysis in C. elegans, suggesting potential as an anti-aging and neuroprotective probiotic.
In vivo experiments showed that L. plantarum SY1 extended the lifespan of C. elegans N2, enhanced oxidative stress resistance, and delayed paralysis in transgenic C. elegans (CL4176) by 23.53%. The strain also demonstrated significant antioxidant capacity with DPPH radical scavenging rate of 49±0.2%, hydroxyl radical scavenging rate of 86.1±0.14%, and superoxide radical anion scavenging rate of 32.7±1.6%.
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Lactiplantibacillus plantarum SY1 extends lifespan, enhances oxidative stress resistance, and delays paralysis in C. elegans, suggesting potential as an anti-aging and neuroprotective probiotic. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 26/100 (low).
The Claim
Lactiplantibacillus plantarum SY1 extends lifespan, enhances oxidative stress resistance, and delays paralysis in C. elegans, suggesting potential as an anti-aging and neuroprotective probiotic.
This conclusion is most relevant to: Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176 (Alzheimer's disease model).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production. (BMC microbiology, 2025) —
How It Works
The proposed biological pathway:
- ▸GABA production by L. plantarum SY1
- ▸Antioxidant activity (scavenging of DPPH, hydroxyl, and superoxide radicals)
- ▸Neuromodulatory effects via GABA as inhibitory neurotransmitter
- ▸Result: Extended lifespan, enhanced stress resistance, and delayed paralysis in C. elegans
Who Might Benefit
Evidence fit by population:
- ▸Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176 (Alzheimer's disease model)
Recommended Dose
N/A (not specified for C. elegans experiments)
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Study conducted in C. elegans model, not in humans or mammals
- ▸No direct measurement of GABA levels in C. elegans or correlation with observed effects
- ▸Optimization of GABA production was done in vitro, not in vivo
Frequently Asked Questions
What is GABA and how does it relate to sleep?▼
GABA (gamma-aminobutyric acid) is a major inhibitory neurotransmitter in the central nervous system that has been shown to alleviate insomnia and other disorders. This study focuses on a GABA-producing probiotic strain.
Did this study test the probiotic on humans?▼
No, the study used C. elegans (nematodes) as an animal model, not human subjects. Human trials would be needed to confirm effects.
What antioxidant effects were observed?▼
L. plantarum SY1 showed DPPH radical scavenging rate of 49±0.2%, hydroxyl radical scavenging rate of 86.1±0.14%, and superoxide radical anion scavenging rate of 32.7±1.6%.
How much GABA did the optimized strain produce?▼
Under optimal conditions (37°C, pH 4.44, 96 hours fermentation, 4.16% inoculum), GABA production reached 1.49 g/L.
References
- 1.Bai X, Shi P, Chu W. “Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production..” BMC microbiology, 2025. PMID: 40442580 DOI: 10.1186/s12866-025-04070-9