Supplements

Lactiplantibacillus plantarum SY1 extends lifespan, enhances oxidative stress resistance, and delays paralysis in C. elegans, suggesting potential as an anti-aging and neuroprotective probiotic.

In vivo experiments showed that L. plantarum SY1 extended the lifespan of C. elegans N2, enhanced oxidative stress resistance, and delayed paralysis in transgenic C. elegans (CL4176) by 23.53%. The strain also demonstrated significant antioxidant capacity with DPPH radical scavenging rate of 49±0.2%, hydroxyl radical scavenging rate of 86.1±0.14%, and superoxide radical anion scavenging rate of 32.7±1.6%.

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score26/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production.

observational

Bai X, Shi P, Chu W · BMC microbiology (2025)

Participants: N/A
Duration: Not specified in abstract
Intervention: Oral administration of GABA-producing Lactiplantibacillus plantarum SY1
Outcome: Lifespan extension, oxidative stress resistance, paralysis delay (23.53%)
Effect Size: 23.53% delay in paralysis
Population: Caenorhabditis elegans N2 (wild-type) and transgenic C. elegans CL4176

Result:

PubMed: 40442580DOI: 10.1186/s12866-025-04070-9

Mechanism Graph

GABA production by L. plantarum SY1
↓
Antioxidant activity (scavenging of DPPH, hydroxyl, and superoxide radicals)
↓
Neuromodulatory effects via GABA as inhibitory neurotransmitter
↓
Result: Extended lifespan, enhanced stress resistance, and delayed paralysis in C. elegans

Limitations

  • ⚠Study conducted in C. elegans model, not in humans or mammals
  • ⚠No direct measurement of GABA levels in C. elegans or correlation with observed effects
  • ⚠Optimization of GABA production was done in vitro, not in vivo

Frequently Asked Questions

What is GABA and how does it relate to sleep?▼

GABA (gamma-aminobutyric acid) is a major inhibitory neurotransmitter in the central nervous system that has been shown to alleviate insomnia and other disorders. This study focuses on a GABA-producing probiotic strain.

Did this study test the probiotic on humans?▼

No, the study used C. elegans (nematodes) as an animal model, not human subjects. Human trials would be needed to confirm effects.

What antioxidant effects were observed?▼

L. plantarum SY1 showed DPPH radical scavenging rate of 49±0.2%, hydroxyl radical scavenging rate of 86.1±0.14%, and superoxide radical anion scavenging rate of 32.7±1.6%.

How much GABA did the optimized strain produce?▼

Under optimal conditions (37°C, pH 4.44, 96 hours fermentation, 4.16% inoculum), GABA production reached 1.49 g/L.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Bai X, Shi P, Chu W. "Probiotic attributes, antioxidant and neuromodulatory effects of GABA-Producing Lactiplantibacillus plantarum SY1 and optimization of GABA production.." BMC microbiology, 2025. PMID: 40442580 DOI: 10.1186/s12866-025-04070-9
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.