Lansoprazole discontinuation improves restless legs syndrome and periodic limb movement disorder symptoms in a hemodialysis patient
A 76-year-old hemodialysis patient with dopaminergic-refractory RLS/PLMD experienced near-complete symptom resolution within 14 days after discontinuing lansoprazole and switching to vonoprazan. The RLS-6 score dropped from 28 to 4, and the Naranjo score was 5, indicating a probable adverse drug reaction.
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Lansoprazole discontinuation improves restless legs syndrome and periodic limb movement disorder symptoms in a hemodialysis patient The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Lansoprazole discontinuation improves restless legs syndrome and periodic limb movement disorder symptoms in a hemodialysis patient
This conclusion is most relevant to: A 76-year-old female hemodialysis patient with end-stage renal disease due to diabetic nephropathy and peptic ulcer disease.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Lansoprazole as a possible trigger of restless legs syndrome with suspected periodic limb movement disorder in a hemodialysis patient: a case report. (CEN case reports, 2026) —
How It Works
The proposed biological pathway:
- ▸Lansoprazole may alter iron or magnesium homeostasis in hemodialysis patients
- ▸Disruption of dopaminergic pathways or other neurotransmitter systems
- ▸Accumulation of drug or metabolites due to renal impairment
- ▸Result: Exacerbation or induction of RLS/PLMD symptoms
Who Might Benefit
Evidence fit by population:
- ▸A 76-year-old female hemodialysis patient with end-stage renal disease due to diabetic nephropathy and peptic ulcer disease
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Single case report, not generalizable to broader populations
- ▸Confounding by prior discontinuation of methyldopa, which partially improved symptoms
- ▸No objective polysomnography or actigraphy to confirm PLMD
References
- 1.Nakata H, Nishiwaki K. “Lansoprazole as a possible trigger of restless legs syndrome with suspected periodic limb movement disorder in a hemodialysis patient: a case report..” CEN case reports, 2026. PMID: 41999568 DOI: 10.1007/s13730-026-01099-1