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Lansoprazole discontinuation improves restless legs syndrome and periodic limb movement disorder symptoms in a hemodialysis patient

A 76-year-old hemodialysis patient with dopaminergic-refractory RLS/PLMD experienced near-complete symptom resolution within 14 days after discontinuing lansoprazole and switching to vonoprazan. The RLS-6 score dropped from 28 to 4, and the Naranjo score was 5, indicating a probable adverse drug reaction.

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism☆☆☆☆☆
Safety☆☆☆☆☆
Confidencelow

Study Evidence

Study 1. Lansoprazole as a possible trigger of restless legs syndrome with suspected periodic limb movement disorder in a hemodialysis patient: a case report.

observational

Nakata H, Nishiwaki K · CEN case reports (2026)

Participants: N/A
Duration: 14 days (post-withdrawal follow-up)
Intervention: Withdrawal of lansoprazole 15 mg/day and transition to vonoprazan
Outcome: RLS/PLMD symptom severity measured by RLS-6 score
Effect Size: N/A (single case report)
Population: A 76-year-old female hemodialysis patient with end-stage renal disease due to diabetic nephropathy

Result:

PubMed: 41999568DOI: 10.1007/s13730-026-01099-1

Mechanism Graph

Lansoprazole may alter iron or magnesium homeostasis in hemodialysis patients
↓
Disruption of dopaminergic pathways or other neurotransmitter systems
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Accumulation of drug or metabolites due to renal impairment
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Result: Exacerbation or induction of RLS/PLMD symptoms

Limitations

  • ⚠Single case report, not generalizable to broader populations
  • ⚠Confounding by prior discontinuation of methyldopa, which partially improved symptoms
  • ⚠No objective polysomnography or actigraphy to confirm PLMD

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References

  1. 1.Nakata H, Nishiwaki K. "Lansoprazole as a possible trigger of restless legs syndrome with suspected periodic limb movement disorder in a hemodialysis patient: a case report.." CEN case reports, 2026. PMID: 41999568 DOI: 10.1007/s13730-026-01099-1
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.