Magnesium-L-theanine (MgT) mitigates chronic stress-induced gut-liver-brain axis disruption in preclinical models
In preclinical studies, MgT preserved intestinal barrier integrity, restored tight junction and mucus-associated proteins, normalized nutrient transporter expression, and attenuated hepatic steatosis, oxidative stress, and iron-driven metabolic damage under chronic variable stress conditions. These effects were linked to reactivation of NAD+/SIRT1 and PPARγ signaling pathways.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Magnesium-L-theanine (MgT) mitigates chronic stress-induced gut-liver-brain axis disruption in preclinical models The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Magnesium-L-theanine (MgT) mitigates chronic stress-induced gut-liver-brain axis disruption in preclinical models
This conclusion is most relevant to: Preclinical animal models (chronic variable stress model).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Multisystem pathology in chronic variable stress: gut-liver-brain axis disruption and the therapeutic promise of magnesium-L-theanine. (Therapeutic advances in endocrinology and metabolism, 2026) —
How It Works
The proposed biological pathway:
- ▸Chronic variable stress induces HPA axis activation and glucocorticoid excess
- ▸This leads to intestinal barrier disruption, dysregulated nutrient transport, hepatic lipid accumulation, and iron dyshomeostasis
- ▸MgT reactivates NAD+/SIRT1 and PPARγ signaling pathways
- ▸Result: Preservation of epithelial barrier, reduced hepatic steatosis, and attenuation of oxidative and inflammatory damage
Who Might Benefit
Evidence fit by population:
- ▸Preclinical animal models (chronic variable stress model)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Evidence is primarily from preclinical animal models, limiting direct translation to humans
- ▸Specific dosing and long-term safety of MgT in human populations are not established in this review
References
- 1.Sahin K, Erek G. “Multisystem pathology in chronic variable stress: gut-liver-brain axis disruption and the therapeutic promise of magnesium-L-theanine..” Therapeutic advances in endocrinology and metabolism, 2026. PMID: 42180808 DOI: 10.1177/20420188261451345