MineralsMagnesium
Magnesium-L-theanine (MgT) mitigates chronic stress-induced gut-liver-brain axis disruption in preclinical models
In preclinical studies, MgT preserved intestinal barrier integrity, restored tight junction and mucus-associated proteins, normalized nutrient transporter expression, and attenuated hepatic steatosis, oxidative stress, and iron-driven metabolic damage under chronic variable stress conditions. These effects were linked to reactivation of NAD+/SIRT1 and PPARγ signaling pathways.
Evidence Score
Evidence Score24/100
Human RCT
Meta-analysis
Mechanism
Safety
Confidencelow
Study Evidence
Study 1. Multisystem pathology in chronic variable stress: gut-liver-brain axis disruption and the therapeutic promise of magnesium-L-theanine.
observationalSahin K, Erek G · Therapeutic advances in endocrinology and metabolism (2026)
Participants: N/A
Duration: N/A
Intervention: Magnesium-L-theanine (MgT) complex, with and without nicotinamide riboside
Outcome: Intestinal barrier integrity (tight junction proteins, mucus-associated proteins), nutrient transporter expression, hepatic steatosis, oxidative stress, iron dyshomeostasis, NAD+/SIRT1 and PPARγ pathway activation
Effect Size: N/A
Population: Preclinical chronic variable stress (CVS) animal models
Result:
Mechanism Graph
Chronic variable stress induces HPA axis activation and glucocorticoid excess
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This leads to intestinal barrier disruption, dysregulated nutrient transport, hepatic lipid accumulation, and iron dyshomeostasis
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MgT reactivates NAD+/SIRT1 and PPARγ signaling pathways
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Result: Preservation of epithelial barrier, reduced hepatic steatosis, and attenuation of oxidative and inflammatory damage
Limitations
- ⚠Evidence is primarily from preclinical animal models, limiting direct translation to humans
- ⚠Specific dosing and long-term safety of MgT in human populations are not established in this review
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References
- 1.Sahin K, Erek G. "Multisystem pathology in chronic variable stress: gut-liver-brain axis disruption and the therapeutic promise of magnesium-L-theanine.." Therapeutic advances in endocrinology and metabolism, 2026. PMID: 42180808 DOI: 10.1177/20420188261451345
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.