Magnesium
An essential mineral involved in GABA regulation and sleep architecture.
Magnesium supplementation improves sleep quality, especially in deficient or elderly populations
Magnesium supplementation (500mg) for 8 weeks significantly improves sleep efficiency, total sleep time, and PSQI scores in elderly adults with primary insomnia. Effects are most pronounced in individuals with magnesium deficiency.
Magnesium supplementation increases slow-wave (deep) sleep and improves sleep architecture
Magnesium supplementation (500mg for 8 weeks) significantly increases slow-wave sleep duration and improves overall sleep architecture in elderly adults with insomnia. The effect is linked to NMDA antagonism and GABA potentiation, which promote deeper, more restorative sleep.
Higher magnesium intake is associated with lower odds of insomnia symptoms in adults without diabetes
In Puerto Rican adults without diabetes, higher total magnesium intake (per 100 mg/d) was associated with 58% lower odds of insomnia symptoms (OR 0.42, 95% CI 0.23-0.79), and magnesium supplement users had 63% lower odds compared to nonusers (OR 0.37, 95% CI 0.17-0.81). This association was not observed in participants with diabetes (P-interaction < 0.05).
Serum magnesium level is associated with cognitive function in Palestinian elderly
In a cross-sectional study of 200 older adults (mean age 64.6 years), serum magnesium levels showed a substantial correlation with cognitive function as measured by the MoCA score. The mean MoCA score was 24.5 Β± 3.66, and magnesium levels were also associated with smoking status and instrumental activities of daily living (IADL), but not with activities of daily living (ADL) or other factors like sleep quality.
Higher magnesium depletion score is associated with increased risk of circadian syndrome, partially mediated by body mass index
In a cross-sectional study of 12,328 U.S. adults from NHANES 2005-2018, higher magnesium depletion score (MDS) was significantly associated with increased risk of circadian syndrome (OR = 1.193, 95% CI: 1.099-1.295, P < 0.001). Body mass index mediated 21% (95% CI: 12.98-34%) of this association.
Nutritional interventions such as carbohydrate, caffeine, creatine, kiwifruit, magnesium, meal timing, protein, and tart cherry may improve sleep duration and quality in athletes.
The review indicates that certain nutritional strategies and supplements have an evidence base for improving sleep in athletes, including carbohydrate, caffeine, creatine, kiwifruit, magnesium, meal make-up and timing, protein, and tart cherry. However, further research is needed to clarify interactions between nutrition and the circadian system. The paper does not provide specific effect sizes or quantitative outcomes.
Obstructive sleep apnea is associated with disturbances in nutrition-related biochemical markers among eutrophic adults
In eutrophic adults, moderate-to-severe OSA was linked to higher VLDL and triglyceride levels, and zinc levels differed across OSA severity groups. Higher AHI was independently associated with higher VLDL and triglycerides and lower magnesium after full adjustment, with sex-specific patterns.
Nutrition, micronutrients, and phytochemicals reduce heat stress-induced depression and related neuropsychological disorders
This review suggests that chronic heat stress induces depression and neuropsychological disorders through HPA axis hyperactivation, oxidative stress, neuroinflammation, mitochondrial dysfunction, and altered neurotransmitter signaling. It proposes that adequate macronutrient intake, micronutrients (B vitamins, vitamin D, magnesium, zinc, selenium, iron), and phytochemicals (polyphenols, flavonoids, carotenoids) can modulate these pathways and enhance resilience against heat-induced depression.
Nutritional interventions, including specific nutrients and dietary patterns, improve sleep quality and manage sleep disorders.
This review synthesizes evidence from clinical trials and observational studies over the past two decades, indicating that nutrients like magnesium, tryptophan, and omega-3 fatty acids, along with dietary patterns such as the Mediterranean diet, enhance sleep outcomes. Functional foods like tart cherry juice and kiwifruit show potential benefits, and the gut microbiome is identified as a key regulator of sleep physiology.
Ultrasound-guided prolotherapy with adjunctive nutritional and metabolic support may lead to rapid radiographic improvement in large multilobulated shoulder calcific tendinitis
A 49-year-old man with acute severe shoulder pain (10/10 VAS) and a large 3 cm multilobulated calcific deposit received ultrasound-guided prolotherapy (10% dextrose with 0.2% lidocaine) plus adjunctive nutritional and metabolic support (vitamin C, vitamin D, magnesium, MSM, L-arginine). At two weeks, pain improved to 2/10, range of motion normalized, and radiographs showed near-complete resorption of the calcific deposit.
Dietary intake of zinc, magnesium, B-group vitamins, vitamin D, and vitamin C is associated with better mental health, memory function, and sleep quality in medical university students.
In a cross-sectional study of 985 medical university students, network analyses identified zinc, magnesium, B-group vitamins, vitamin D, and vitamin C as central micronutrients associated with mental health, memory function, and sleep quality. The study found high prevalence of depression (49.2%), anxiety (49.7%), stress (62.9%), and sleep disturbances (54.3%) among participants.
Magnesium supplementation improves sleep quality in type 2 diabetes patients
A cross-sectional survey of 132 participants from a randomized, double-blind clinical trial on magnesium supplementation in type 2 diabetes found that over half reported symptom improvements, including in sleep quality. Satisfaction was high, with 75% willing to join future trials and 87.88% would recommend participation.
Specific nutrients (e.g., magnesium, tryptophan, omega-3 fatty acids) and dietary patterns rich in anti-inflammatory and antioxidant compounds improve sleep outcomes.
This review synthesizes evidence from clinical trials, observational studies, and mechanistic research over the past two decades, indicating that nutrients like magnesium, tryptophan, and omega-3 fatty acids, along with anti-inflammatory dietary patterns, enhance sleep quality. Functional foods such as tart cherry juice and kiwifruit also show potential benefits. The gut microbiome is identified as a significant regulator of sleep physiology, suggesting probiotics and prebiotics as novel interventions.
Magnesium supplementation improves sleep quality in adults with type 2 diabetes
In a cross-sectional survey of 132 participants from a randomized, double-blind clinical trial on magnesium supplementation in type 2 diabetes, over half reported symptom improvements including in sleep quality. Satisfaction was high, with 75% willing to join future trials and 87.88% would recommend participation.
Magnesium supplementation is associated with high participant satisfaction and perceived improvements in sleep quality in adults with type 2 diabetes
In a cross-sectional survey of 132 participants from a randomized, double-blind clinical trial on magnesium supplementation in type 2 diabetes, 87.88% would recommend participation and over half reported symptom improvements, including in sleep quality. Satisfaction scores were consistently positive, with high internal consistency (Cronbach's alpha=0.93) and strong construct validity.
Combined apigenin and magnesium (A+M) synergistically enhances sleep duration in normal and insomnia mouse models
In normal mice, A+M treatment increased sleep duration by 44% (p<0.005). In caffeine-induced sleep disturbed mice, sleep duration increased by 32% (p<0.001), and in PCPA-induced insomnia mice, by 37% (p<0.05). These effects surpassed individual treatments of apigenin or magnesium alone.
Combined apigenin and magnesium synergistically enhance sleep duration in normal and insomnia mouse models
The combination of apigenin and magnesium (A+M) significantly increased sleep duration by 44% in normal mice, 32% in caffeine-induced sleep-disturbed mice, and 37% in PCPA-induced insomnia mice, outperforming individual treatments. Mechanistically, A+M suppressed systemic and hypothalamic TNFΞ± levels and inhibited microglial activation via NFΞΊB signaling.
Combined apigenin and magnesium (A+M) enhances sleep duration in normal and insomnia mouse models
The combination of apigenin and magnesium significantly increased sleep duration in normal mice by 44%, in caffeine-induced sleep-disturbed mice by 32%, and in PCPA-induced insomnia mice by 37%, outperforming individual treatments. The effect was linked to suppression of TNFΞ± levels and inhibition of microglial activation via NFΞΊB signaling.
Magnesium-L-theanine (MgT) protects intestinal barrier integrity and reduces hepatic steatosis in chronic variable stress models
In preclinical chronic variable stress (CVS) models, MgT preserved epithelial barrier architecture, restored tight junction and mucus-associated proteins, normalized intestinal nutrient transporter expression, and attenuated hepatic steatosis, oxidative stress, and iron-driven metabolic damage. These effects were linked to reactivation of NAD+/SIRT1 and PPARΞ³ signaling pathways, with co-administration of nicotinamide riboside further potentiating responses.
Magnesium-L-theanine (MgT) mitigates chronic stress-induced gut-liver-brain axis disruption in preclinical models
In preclinical studies, MgT preserved intestinal barrier integrity, restored tight junction and mucus-associated proteins, normalized nutrient transporter expression, and attenuated hepatic steatosis, oxidative stress, and iron-driven metabolic damage under chronic variable stress conditions. These effects were linked to reactivation of NAD+/SIRT1 and PPARΞ³ signaling pathways.