Multi-herb formula (VL-G-A57) and full-spectrum ashwagandha (VL-G-E12) improve sleep quality in stressed adults
In a 60-day randomized, double-blind, placebo-controlled trial, both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (ashwagandha) significantly improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) compared to placebo. VL-G-A57 showed p=0.0008 and VL-G-E12 showed p<0.0001 for PSQI improvement, with corresponding improvements in restorative sleep (RSQ-W, p<0.0001 for both).
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Multi-herb formula (VL-G-A57) and full-spectrum ashwagandha (VL-G-E12) improve sleep quality in stressed adults The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Multi-herb formula (VL-G-A57) and full-spectrum ashwagandha (VL-G-E12) improve sleep quality in stressed adults
This conclusion is most relevant to: Adults aged 18-65 years with BMI 18-29.9 kg/m² and high stress levels.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study. (Trials, 2026) —
How It Works
The proposed biological pathway:
- ▸Adaptogens modulate HPA axis activity
- ▸Reduction in cortisol and stress response
- ▸Improved regulation of sleep-wake cycle
- ▸Result: Improved sleep quality and restorative sleep
Who Might Benefit
Evidence fit by population:
- ▸Adults aged 18-65 years with BMI 18-29.9 kg/m² and high stress levels
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸No specific effect size or confidence intervals reported for sleep outcomes
- ▸Mental alertness showed no significant improvement, suggesting limited cognitive benefits
Frequently Asked Questions
What is VL-G-A57?▼
VL-G-A57 is a multi-herb formula containing Rhodiola, holy basil, and Schisandra chinensis, tested as an adaptogen for stress and sleep improvement.
How was sleep quality measured in this study?▼
Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and the Restorative Sleep Questionnaire-Weekly (RSQ-W).
Did both interventions improve sleep?▼
Yes, both VL-G-A57 and VL-G-E12 (ashwagandha) significantly improved PSQI scores and restorative sleep compared to placebo at day 60.
Was the study well-designed?▼
Yes, it was a randomized, double-blind, placebo-controlled trial with 186 participants and a priori power analysis, registered on ClinicalTrials.gov.
References
- 1.McKinney E, Stewart J, Kewalramani R, Singh S. “Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study..” Trials, 2026. PMID: 41656269 DOI: 10.1186/s13063-026-09495-9