Multi-herb formula (VL-G-A57) and full-spectrum ashwagandha (VL-G-E12) improve sleep quality in stressed adults

Q: What is VL-G-A57?

VL-G-A57 is a multi-herb formula containing Rhodiola, holy basil, and Schisandra chinensis, tested as an adaptogen for stress and sleep improvement.

Q: How was sleep quality measured in this study?

Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and the Restorative Sleep Questionnaire-Weekly (RSQ-W).

Q: Did both interventions improve sleep?

Yes, both VL-G-A57 and VL-G-E12 (ashwagandha) significantly improved PSQI scores and restorative sleep compared to placebo at day 60.

Q: Was the study well-designed?

Yes, it was a randomized, double-blind, placebo-controlled trial with 186 participants and a priori power analysis, registered on ClinicalTrials.gov.

In a 60-day randomized, double-blind, placebo-controlled trial, both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (ashwagandha) significantly improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) compared to placebo. VL-G-A57 showed p=0.0008 and VL-G-E12 showed p<0.0001 for PSQI improvement, with corresponding improvements in restorative sleep (RSQ-W, p<0.0001 for both).

Last updated: Jul 7, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100

Human RCT★★☆☆☆

Meta-analysis☆☆☆☆☆

Mechanism★★★★★

Safety★★★★☆

Confidencelow

Study Evidence

Study 1. Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.

observational

McKinney E, Stewart J, Kewalramani R, Singh S · Trials (2026)

Participants: N/A

Duration: 60 days

Intervention: VL-G-A57 (formula containing Rhodiola, holy basil, and Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha root formula)

Outcome: Sleep quality (Pittsburgh Sleep Quality Index, PSQI) and restorative sleep (Restorative Sleep Questionnaire-Weekly, RSQ-W)

Effect Size: N/A

Population: Individuals aged 18 to 65 years with high stress and BMI 18-29.9 kg/m²

Result:

PubMed: 41656269 DOI: 10.1186/s13063-026-09495-9

Mechanism Graph

Adaptogens modulate HPA axis activity

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Reduction in cortisol and stress response

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Improved regulation of sleep-wake cycle

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Result: Improved sleep quality and restorative sleep

Limitations

⚠No specific effect size or confidence intervals reported for sleep outcomes
⚠Mental alertness showed no significant improvement, suggesting limited cognitive benefits

Frequently Asked Questions

What is VL-G-A57?▼

VL-G-A57 is a multi-herb formula containing Rhodiola, holy basil, and Schisandra chinensis, tested as an adaptogen for stress and sleep improvement.

How was sleep quality measured in this study?▼

Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI) and the Restorative Sleep Questionnaire-Weekly (RSQ-W).

Did both interventions improve sleep?▼

Yes, both VL-G-A57 and VL-G-E12 (ashwagandha) significantly improved PSQI scores and restorative sleep compared to placebo at day 60.

Was the study well-designed?▼

Yes, it was a randomized, double-blind, placebo-controlled trial with 186 participants and a priori power analysis, registered on ClinicalTrials.gov.

Products

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References

1.McKinney E, Stewart J, Kewalramani R, Singh S. "Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study.." Trials, 2026. PMID: 41656269 DOI: 10.1186/s13063-026-09495-9

Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.