Ashwagandha
An adaptogen studied for stress reduction and sleep quality improvement.
Ashwagandha root extract (300mg BID) significantly improves sleep quality and reduces sleep onset latency in adults with insomnia
A well-designed 8-week RCT (n=138) found ashwagandha root extract significantly improved PSQI scores, reduced sleep onset latency, and improved sleep efficiency. Benefits were most pronounced in adults with insomnia and anxiety.
Ashwagandha root extract improves cognitive performance and sleep quality in children aged 6-12 years
An 8-week randomized, double-blind, placebo-controlled trial in 85 children (73 completers) found that Ashwagandha root extract (ARE) gummies (150 mg twice daily) significantly improved speed of information processing, delayed word recall, Stroop task accuracy, Corsi block span, and choice reaction time accuracy compared to placebo. Parent-reported sleep quality also improved on the Sleep Disturbance Scale for Children (SDSC), with no significant adverse events.
Withania somnifera (Ashwagandha) reduces perceived stress and improves sleep quality compared to placebo
The systematic review found that Withania somnifera (Ashwagandha) showed beneficial signals for stress and sleep outcomes based on controlled human studies. Meta-analysis was feasible for this node versus placebo on perceived stress and sleep quality, though confidence in effect magnitude is limited by heterogeneity and small-study effects.
Withania somnifera improves anxiety symptoms in individuals with mental disorders
This systematic review and meta-analysis of 14 RCTs found that Withania somnifera significantly reduced anxiety symptoms compared to controls, with an outlier-corrected standardized mean difference of -1.13 (95% CI: -1.65 to -0.60). The effect was confirmed using Bayesian analysis for anxiety, but not for depression. The median dose was 600 mg/day over 8 weeks.
Withania somnifera (Ashwagandha) improves anxiety symptoms in individuals with mental disorders
A systematic review and meta-analysis of 14 RCTs (360 treated, 353 controls) found that Withania somnifera significantly reduced anxiety symptoms (outlier-corrected SMD: -1.13, 95% CI: -1.65 to -0.60) compared to controls. The effect was confirmed using Bayesian analysis for anxiety but not for depression. No significant differences in safety or tolerability were found.
Shatavari root extract combined with Ashwagandha improves female sexual function, mood, and happiness in women with sexual health concerns.
In an 8-week RCT with 135 women, the combination of Shatavari and Ashwagandha (SHT-ARE) significantly improved total FSFI scores (P=0.005), arousal (P=0.041), lubrication (P=0.027), and orgasm (P=0.031) compared to placebo. The SHT-ARE group also showed reduced sexual distress (FSDS, P<0.0001), improved happiness (OHQ, P<0.0001), and reduced mood disturbances (POMS, P<0.0001).
Ashwagandha root extract improves ADHD symptoms and executive functioning in children and adolescents with mild ADHD
In a randomized, double-blind, placebo-controlled trial, 58 children and adolescents with mild ADHD received either 150 mg of ashwagandha root extract or placebo twice daily for 56 days. At Day 56, the ashwagandha group showed significantly lower ADHD-RS-IV total, inattention, and hyperactivity-impulsivity scores compared to placebo (P < 0.001), along with significant improvements in executive functioning (BRIEF-2) and patient-reported outcomes (PROMIS sleep disturbance and anxiety). No serious adverse events were reported.
Shatavari root extract combined with Ashwagandha improves sexual arousal, lubrication, orgasm, and total FSFI scores in women with sexual health concerns.
In an 8-week randomized controlled trial of 135 women, the combination of Shatavari and Ashwagandha root extracts (SHT-ARE) significantly improved Female Sexual Function Index (FSFI) scores for arousal (P=0.041), lubrication (P=0.027), orgasm (P=0.031), and total FSFI (P=0.005) compared to placebo. Shatavari alone improved only total FSFI (P=0.025) and satisfaction (P<0.0001). The SHT-ARE group also showed reduced sexual distress (FSDS, P<0.0001) and increased happiness (OHQ, P<0.0001).
Ashwagandha root extract improves sleep quality and reduces perceived stress in pregnant women
In a 12-week RCT of 70 pregnant women in their second trimester, Ashwagandha root extract (ARE) 300 mg twice daily plus standard care significantly improved subjective sleep quality at all visits (p=0.036), sleep duration at weeks 8 and 12 (p<0.001), and sleep disturbances at week 12 (p=0.028) compared to standard care alone. Perceived stress was also significantly reduced with ARE (-10.50 vs. -5.35; p<0.001).
Ashwagandha root extract improves sleep quality in pregnant women
In a 12-week RCT, Ashwagandha root extract (ARE) 300 mg twice daily plus standard care significantly improved subjective sleep quality at all visits (p=0.036), sleep duration at weeks 8 and 12 (p<0.001), and sleep disturbances at week 12 (p=0.028) compared to standard care alone in pregnant women in their second trimester. No adverse events were reported.
Ashwagandha root extract sustained-release (AshwaSR) 150 mg and 300 mg capsules reduce perceived stress and improve sleep quality in healthy stressed adults.
In a randomized, double-blind, placebo-controlled trial, healthy adults with moderate stress (Perceived Stress Scale score 14-26) taking AshwaSR 150 mg or 300 mg daily for 60 days showed significant reductions in perceived stress (38.6% and 41.6% reduction, respectively) and significant improvements in sleep quality compared to placebo. Serum cortisol was significantly reduced only in the 300 mg group.
Ashwagandha root extract improves sleep quality in children aged 6-12 years
In a randomized, double-blind, placebo-controlled trial, 73 children aged 6-12 years completed an 8-week supplementation with Ashwagandha root extract (ARE) gummies (150 mg twice daily) or placebo. Parent-reported sleep quality, measured by the Sleep Disturbance Scale for Children (SDSC), significantly improved in the ARE group (p = 0.035).
Multi-herb formula (VL-G-A57) and full-spectrum ashwagandha (VL-G-E12) improve sleep quality in stressed adults
In a 60-day randomized, double-blind, placebo-controlled trial, both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (ashwagandha) significantly improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) compared to placebo. VL-G-A57 showed p=0.0008 and VL-G-E12 showed p<0.0001 for PSQI improvement, with corresponding improvements in restorative sleep (RSQ-W, p<0.0001 for both).
Ashwagandha, chamomile, dark chocolate, ginseng, green tea, lavender, lion's mane mushroom, maca, tart cherries, turmeric, and valerian root may improve mental energy outcomes in adults without severe disease.
This scoping review of 101 randomized controlled trials evaluated 16 dietary ingredients for effects on mental energy. Eleven ingredients showed promising directional benefits (≥20% of outcomes improved) across cognition, mood, and sleep domains, with dark chocolate, ginseng, ashwagandha, and lion's mane mushroom being most promising for cognition.
Multi-herb formula (VL-G-A57) and ashwagandha (VL-G-E12) improve sleep quality in stressed adults
In a 60-day RCT, both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha) significantly improved sleep quality as measured by PSQI compared to placebo (VL-G-A57: p=0.0008; VL-G-E12: p<0.0001). Restorative sleep also improved significantly in both groups (p<0.0001).
Shatavari root extract combined with Ashwagandha root extract improves sexual arousal, lubrication, orgasm, and total Female Sexual Function Index scores in women.
In an 8-week randomized, double-blind, placebo-controlled trial with 135 women, the combination of Shatavari and Ashwagandha root extracts (SHT-ARE) significantly improved FSFI Arousal (P = 0.041), Lubrication (P = 0.027), Orgasm (P = 0.031), and Total FSFI (P = 0.005) scores compared to placebo. The SHT-ARE group also showed reduced sexual distress (FSDS, P < 0.0001), increased happiness (OHQ, P < 0.0001), and improved mood (POMS, P < 0.0001) versus placebo.
Ashwagandha root extract sustained-release (AshwaSR) reduces perceived stress and improves sleep quality in healthy stressed adults
In a randomized, double-blind, placebo-controlled trial, AshwaSR 150 mg and 300 mg capsules significantly reduced Perceived Stress Scale scores by 38.6% and 41.6% respectively from baseline to day 60 (P < .001). Both doses also significantly improved sleep quality, psychological well-being, and eating behavior compared to placebo, with the 300 mg dose additionally reducing serum cortisol levels (P < .05).
Both VL-G-A57 (Rhodiola, holy basil, Schisandra chinensis) and VL-G-E12 (full-spectrum ashwagandha) improve sleep quality in individuals with high stress
In a 60-day randomized, double-blind, placebo-controlled trial involving 186 participants with high stress, both VL-G-A57 and VL-G-E12 significantly improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) compared to placebo (VL-G-A57: p=0.0008, VL-G-E12: p<0.0001). Restorative Sleep Questionnaire-Weekly (RSQ-W) results also showed significant improvements in both active groups versus placebo (p<0.0001).
Withania somnifera (ashwagandha) enhances stress resilience and improves quality of life in stressed individuals
This review highlights that Withania somnifera (ashwagandha) shows consistent efficacy in enhancing stress resilience and improving quality of life. The claim is based on clinical trial data confirming the management of stress symptoms, including reduction of anxiety, improvement in mood stability, modulation of cortisol levels, improvement in sleep patterns, and enhancement of mental well-being.
Standardized ashwagandha extracts improve sleep quality in stressed adults
Clinical trials with standardized ashwagandha extracts have shown reductions in stress-related biomarkers and improvements in sleep quality. The review highlights these effects as part of ashwagandha's adaptogenic and neuroimmune regulatory properties.
Ashwagandha ingestion is temporally associated with acute neurotoxicity including prolonged sleep, abnormal sleep behaviors, acute confusion, and retrograde amnesia.
A 40-year-old man developed prolonged sleep, abnormal sleep behaviors, acute confusion, and retrograde amnesia after ingesting ashwagandha. Comprehensive evaluation excluded other causes, and symptoms resolved completely upon discontinuation and supportive care.
Plant-derived compounds, including phenylpropanoids, tetracyclic triterpenoids, and lignans, improve sleep patterns in stressed individuals
This review reports that recent clinical trial data confirm the efficacy of plant-derived compounds in managing stress symptoms, including improvement in sleep patterns. The review highlights adaptogenic herbs such as Withania somnifera (ashwagandha) for enhancing stress resilience and quality of life.
Standardized ashwagandha extracts improve sleep quality in adults with stress-related sleep complaints
Clinical trials with standardized ashwagandha extracts have shown reductions in stress-related biomarkers and improvements in sleep quality. The review notes improvements in sleep parameters, though specific effect sizes are not provided in the abstract.
Ashwagandha improves sleep quality in adults
Ashwagandha (Withania somnifera) is reported to improve sleep quality, as part of its adaptogenic and stress-reducing effects. The narrative review highlights its efficacy in mitigating stress-related markers and enhancing sleep, though specific numerical data are not provided in the abstract.
Withania somnifera (ashwagandha) improves sleep patterns and stress resilience in adults with stress-related symptoms
This review highlights that adaptogenic herbs like Withania somnifera (ashwagandha) show consistent efficacy in enhancing stress resilience and improving quality of life, including improvement in sleep patterns. Clinical trial data confirm the role of plant-derived compounds in modulating cortisol levels and reducing anxiety, with ashwagandha being a key example.
Nutraceuticals such as valerian, chamomile, and ashwagandha improve sleep quality in individuals with sleep disorders
This review paper reports that nutraceuticals including Artemisia annua, valerian, rosemary, jujube, passionflower, lemon balm, ashwagandha, kava-kava, lavender, and chamomile have shown remarkable benefits in the therapy of sleep disorders. These remedies modulate neurotransmitter and hormonal pathways within sleep circuits and enhance sleep quality by alleviating stress, inflammation, and oxidative stress. The paper is a narrative review summarizing clinical studies that validated the efficacy of natural sleep aids.
Standardized ashwagandha extracts improve sleep quality in clinical trials
Clinical trials with standardized ashwagandha extracts have shown improvements in sleep quality and mood parameters, along with reductions in stress-related biomarkers. The review highlights these effects as part of ashwagandha's adaptogenic and neuroimmune regulatory properties.
Plant-derived compounds, particularly phenylpropanoids, improve sleep patterns in stressed individuals
This review reports that recent clinical trial data confirm the efficacy of plant-derived compounds (phenylpropanoids, tetracyclic triterpenoids, lignans) in managing stress symptoms, including improvement in sleep patterns. Adaptogenic herbs like Withania somnifera (ashwagandha) show consistent efficacy in enhancing stress resilience and quality of life.
Withania somnifera preparations may influence sleep-related outcomes in humans
The review summarizes evidence from preclinical and human studies suggesting that Withania somnifera (Ashwagandha) preparations may affect stress-related and sleep-related outcomes. However, heterogeneity in extract composition and study design limits firm conclusions, and the overall strength of evidence varies across indications and products.
Ayurvedic Vata-pacifying and Rasayana interventions improve visual acuity and anatomical resolution in CSR patients with Vata Prakriti
Three CSR patients (two males aged 65 and 46, one female aged 40) with confirmed Vata Prakriti received a standardized Ayurvedic regimen including Ashwagandha, Punarnavadi Kashaya, Tiktaka Ghrita, Kalyanaka Ghrita, Triphala Churna, and local ocular therapies. All three showed marked improvement in visual acuity and complete anatomical resolution of macular fluid on OCT within 4-17 months, with no recurrence over 1 year follow-up.
Ashwagandha improves sleep quality in older adults
The review reports that clinical trials have consistently shown Ashwagandha's efficacy in improving sleep quality in older adults. This is part of its broader geroprotective benefits, including enhanced muscle strength, cardiorespiratory fitness, and cognitive function.
Withania somnifera preparations may influence stress-related and sleep-related outcomes
This narrative review of literature from 2015 to 2026 suggests that Withania somnifera (Ashwagandha) preparations may affect stress and sleep outcomes, based on preclinical and human studies. However, heterogeneity in extract composition and study design limits firm conclusions, and the overall strength of evidence varies across indications and products.
Ashwagandha extract improves sleep quality in adults with stress-related sleep complaints
Clinical trials with standardized ashwagandha extracts have shown reductions in stress-related biomarkers along with improvements in sleep quality. The review highlights that ashwagandha's effects on sleep are mediated through modulation of the HPA axis and GABAergic signaling.
Ashwagandha supplementation at 330-1000 mg daily increases endurance and facilitates quicker recoveries in athletes
The narrative review reports that ashwagandha dosages of 330-1000 mg daily increase endurance and speed recovery, with a twice-daily dose of 300 mg combined with weight training enhancing muscular strength and hypertrophy. Typical dosage in sports is approximately 600 mg/day, with lower doses for less active individuals.
Ashwagandha supplementation increases endurance and facilitates quicker recoveries in athletes
Studies suggest that Ashwagandha dosages of 330-1000 mg daily increase endurance and facilitate quicker recoveries. A twice daily dose of 300 mg in combination with weight training increases muscular strength and hypertrophy. Typical dosage in the sporting field is approximately 600 mg/day.
Nutraceuticals such as Artemisia annua, valerian, rosemary, jujube, passionflower, lemon balm, ashwagandha, kava-kava, lavender, and chamomile improve sleep quality and duration in individuals with sleep disorders.
This review paper summarizes evidence that various nutraceuticals (herbal and dietary supplements) have remarkable benefits in treating sleep disorders. These remedies modulate neurotransmitter and hormonal pathways in sleep circuits and indirectly improve sleep by alleviating stress, inflammation, and oxidative stress. The paper notes that conventional sleep medications are habit-forming with withdrawal effects, making nutraceuticals a non-toxic, non-habit-forming alternative.
Ashwagandha supplementation improves athletic performance and recovery by increasing endurance, strength, and hypertrophy while reducing cortisol levels and anxiety
Studies indicate that ashwagandha dosages of 330-1000 mg daily increase endurance and facilitate quicker recoveries. A twice-daily dose of 300 mg combined with weight training increases muscular strength and hypertrophy, and the supplement is believed to regulate cortisol levels and relieve anxiety and insomnia.
Ashwagandha root powder and extracts improve sleep and reduce anxiety in humans
Ashwagandha (Withania somnifera L.) has been used in Ayurvedic medicine to improve sleep and anxiety, with recent scientific investigations showing promise for relief from insomnia and stress. The review notes that millions of people take ashwagandha daily with very few reported side effects, suggesting safety.