HerbsAshwagandha

Withania somnifera preparations may influence sleep-related outcomes in humans

The review summarizes evidence from preclinical and human studies suggesting that Withania somnifera (Ashwagandha) preparations may affect stress-related and sleep-related outcomes. However, heterogeneity in extract composition and study design limits firm conclusions, and the overall strength of evidence varies across indications and products.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Nutraceutical Applications of Withania somnifera: The Scientific Knowledge for Rational Modern Use of the "Ayurvedic Adaptogen".

observational

Pandey S, Pant P, Corbioli G, Bonazzi E, Cisneros-Yupanqui M, Salmaso P, Dall'Acqua S · Foods (Basel, Switzerland) (2026)

Participants: N/A
Duration: N/A
Intervention: Withania somnifera (Ashwagandha) preparations (various extracts)
Outcome: Sleep-related outcomes (e.g., sleep quality, sleep onset, duration)
Effect Size: N/A
Population: Humans (general, including those with stress-related complaints) and preclinical models

Result:

PubMed: 42354160DOI: 10.3390/foods15122192

Mechanism Graph

Modulation of stress response pathways (e.g., HPA axis)
↓
Reduction of cortisol levels
↓
Neuroprotective effects via antioxidant and anti-inflammatory pathways
↓
Result: Improved sleep quality and reduced sleep disturbances

Limitations

  • ⚠Heterogeneity in extract composition and study design across reviewed studies
  • ⚠Overall strength of evidence varies across indications and products, limiting generalizability

Frequently Asked Questions

What is Withania somnifera?▼

Withania somnifera, commonly known as Ashwagandha, is an adaptogenic herb used in Ayurvedic medicine, often included in nutraceuticals and dietary supplements for stress and sleep support.

Does Ashwagandha improve sleep?▼

Some evidence from human studies suggests Ashwagandha preparations may improve sleep-related outcomes, but results vary due to differences in extract composition and study quality.

What is the recommended dose of Ashwagandha for sleep?▼

The review does not specify a recommended dose due to heterogeneity in studies; standardized preparations are needed for clearer dosing guidelines.

Is Ashwagandha safe for long-term use?▼

The review notes that long-term safety data are limited, and further well-designed trials are needed to assess safety and efficacy.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Pandey S, Pant P, Corbioli G, Bonazzi E, Cisneros-Yupanqui M, Salmaso P, Dall'Acqua S. "Nutraceutical Applications of Withania somnifera: The Scientific Knowledge for Rational Modern Use of the "Ayurvedic Adaptogen".." Foods (Basel, Switzerland), 2026. PMID: 42354160 DOI: 10.3390/foods15122192
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.