HerbsAshwagandha

Standardized ashwagandha extracts improve sleep quality in clinical trials

Clinical trials with standardized ashwagandha extracts have shown improvements in sleep quality and mood parameters, along with reductions in stress-related biomarkers. The review highlights these effects as part of ashwagandha's adaptogenic and neuroimmune regulatory properties.

Last updated: Jul 7, 2026โ€ข0 RCTsโ€ข๐Ÿ“– Read as article โ†’

Evidence Score

Evidence Score32/100
Human RCTโ˜†โ˜†โ˜†โ˜†โ˜†
Meta-analysisโ˜†โ˜†โ˜†โ˜†โ˜†
Mechanismโ˜†โ˜†โ˜†โ˜†โ˜†
Safetyโ˜†โ˜†โ˜†โ˜†โ˜†
Confidencelow

Study Evidence

Study 1. Ashwagandha as an Adaptogenic Herb: A Comprehensive Review of Immunological and Neurological Effects.

observational

Jamnekar PP, Dehankar TJ, Bedre RV, Dharan BG, Agravat B, Agravat H ยท Cureus (2025)

Participants: N/A
Duration: N/A
Intervention: Standardized ashwagandha (Withania somnifera) extracts
Outcome: Sleep quality, stress-related biomarkers, mood parameters
Effect Size: N/A
Population: Adults with stress-related complaints (clinical trial participants)

Result:

PubMed: 41356880DOI: 10.7759/cureus.96183

Mechanism Graph

Modulation of hypothalamic-pituitary-adrenal (HPA) axis
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Inhibition of NF-ฮบB and induction of Nrf2 activation
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Effects on GABAergic signaling
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Result: Anti-inflammatory, antioxidant, and anxiolytic actions leading to improved sleep

Limitations

  • โš Heterogeneity in the preparation of extracts across studies
  • โš Small sample sizes and variability in endpoints
  • โš Possible funding-related biases

Products

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References

  1. 1.Jamnekar PP, Dehankar TJ, Bedre RV, Dharan BG, Agravat B, Agravat H. "Ashwagandha as an Adaptogenic Herb: A Comprehensive Review of Immunological and Neurological Effects.." Cureus, 2025. PMID: 41356880 DOI: 10.7759/cureus.96183
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.