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Neiyanggong reduces cancer-related fatigue and improves sleep quality in breast cancer patients undergoing chemotherapy.

A randomized controlled trial of 72 breast cancer patients undergoing chemotherapy found that a staged progressive dynamic-static Neiyanggong intervention significantly reduced cancer-related fatigue (PFS-R total score interaction effect F=94.810, P<0.001, η²=0.807) and improved sleep quality (PSQI total score interaction effect Wald χ²=292.975, P<0.001) compared to routine care. After three chemotherapy cycles, fatigue scores were significantly lower in the Neiyanggong group (P<0.05), and notable improvements were seen in sleep latency, sleep efficiency, and daytime dysfunction (P<0.001).

1 min read•Updated Aug 5, 2026•1 RCTs•View structured evidence →
Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.

Neiyanggong reduces cancer-related fatigue and improves sleep quality in breast cancer patients undergoing chemotherapy. The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).

The Claim

Neiyanggong reduces cancer-related fatigue and improves sleep quality in breast cancer patients undergoing chemotherapy.

This conclusion is most relevant to: Breast cancer patients undergoing chemotherapy (n=72, 36 per group)..

What the Research Shows

The conclusion draws on 1 linked study. Highlights from the cited literature:

  • ▸Effects of Neiyanggong on cancer-related fatigue in breast cancer patients undergoing chemotherapy: a randomized controlled trial. (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026) — A randomized controlled trial of 72 breast cancer patients undergoing chemotherapy found that a staged progressive dynamic-static Neiyanggong intervention significantly reduced cancer-related fatigue (PFS-R total score interaction effect F=94.810, P<0.001, η²=0.807) and improved sleep quality (PSQI total score interaction effect Wald χ²=292.975, P<0.001) compared to routine care. After three chemotherapy cycles, fatigue scores were significantly lower in the Neiyanggong group (P<0.05), and notable improvements were seen in sleep latency, sleep efficiency, and daytime dysfunction (P<0.001).

How It Works

The proposed biological pathway:

  • ▸Neiyanggong combines dynamic and static exercises tailored to disease characteristics
  • ▸Practiced progressively over three chemotherapy cycles
  • ▸May reduce fatigue and improve sleep through mind-body regulation and physical activity
  • ▸Result: Significant reduction in fatigue and improvement in sleep quality

Who Might Benefit

Evidence fit by population:

  • ▸Breast cancer patients undergoing chemotherapy (n=72, 36 per group).

Limitations & Caveats

Important context when interpreting this evidence:

  • ▸Single-center study with relatively small sample size (n=72)
  • ▸No blinding of participants or practitioners due to the nature of the intervention

Frequently Asked Questions

What is Neiyanggong?▼

Neiyanggong is a mind-body exercise combining dynamic and static movements, adapted here as a staged progressive intervention for breast cancer patients.

How was sleep quality measured in this study?▼

Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which evaluates components like sleep latency, sleep efficiency, and daytime dysfunction.

Did the Neiyanggong group experience any side effects?▼

No adverse events occurred in the Neiyanggong group, and adherence to the intervention was high.

Is this intervention suitable for all breast cancer patients?▼

The study focused on patients undergoing chemotherapy, and the intervention was tailored to disease-specific characteristics. Generalizability may be limited by the single-center design and small sample size.

References

  1. 1.Du Y, Wang J, Zhang C, Guo Q, Hao X, Zhang W, Jiao G. “Effects of Neiyanggong on cancer-related fatigue in breast cancer patients undergoing chemotherapy: a randomized controlled trial..” Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. PMID: 42498825 DOI: 10.1007/s00520-026-11029-7
Disclaimer: This article is auto-generated from structured research data for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.