Supplements

Neiyanggong reduces cancer-related fatigue and improves sleep quality in breast cancer patients undergoing chemotherapy.

Q: What is Neiyanggong?

Neiyanggong is a mind-body exercise combining dynamic and static movements, adapted here as a staged progressive intervention for breast cancer patients.

Q: How was sleep quality measured in this study?

Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which evaluates components like sleep latency, sleep efficiency, and daytime dysfunction.

Q: Did the Neiyanggong group experience any side effects?

No adverse events occurred in the Neiyanggong group, and adherence to the intervention was high.

Q: Is this intervention suitable for all breast cancer patients?

The study focused on patients undergoing chemotherapy, and the intervention was tailored to disease-specific characteristics. Generalizability may be limited by the single-center design and small sample size.

A randomized controlled trial of 72 breast cancer patients undergoing chemotherapy found that a staged progressive dynamic-static Neiyanggong intervention significantly reduced cancer-related fatigue (PFS-R total score interaction effect F=94.810, P<0.001, η²=0.807) and improved sleep quality (PSQI total score interaction effect Wald χ²=292.975, P<0.001) compared to routine care. After three chemotherapy cycles, fatigue scores were significantly lower in the Neiyanggong group (P<0.05), and notable improvements were seen in sleep latency, sleep efficiency, and daytime dysfunction (P<0.001).

Last updated: Aug 5, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100

Human RCT★★☆☆☆

Meta-analysis☆☆☆☆☆

Mechanism★★★★★

Safety★★★★☆

Confidencelow

Study Evidence

Study 1. Effects of Neiyanggong on cancer-related fatigue in breast cancer patients undergoing chemotherapy: a randomized controlled trial.

rct

Du Y, Wang J, Zhang C, Guo Q, Hao X, Zhang W, Jiao G · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2026)

Participants: 72

Duration: Three chemotherapy cycles

Intervention: Staged progressive dynamic-static Neiyanggong program practiced across three chemotherapy cycles, in addition to routine treatment and nursing care.

Outcome: Cancer-related fatigue (Piper Fatigue Scale-Revised, PFS-R) and sleep quality (Pittsburgh Sleep Quality Index, PSQI) including subcomponents sleep latency, sleep efficiency, and daytime dysfunction.

Effect Size: η²=0.807 for PFS-R interaction effect

Population: Breast cancer patients undergoing chemotherapy (n=72, 36 per group).

Result: A randomized controlled trial of 72 breast cancer patients undergoing chemotherapy found that a staged progressive dynamic-static Neiyanggong intervention significantly reduced cancer-related fatigue (PFS-R total score interaction effect F=94.810, P<0.001, η²=0.807) and improved sleep quality (PSQI total score interaction effect Wald χ²=292.975, P<0.001) compared to routine care. After three chemotherapy cycles, fatigue scores were significantly lower in the Neiyanggong group (P<0.05), and notable improvements were seen in sleep latency, sleep efficiency, and daytime dysfunction (P<0.001).

PubMed: 42498825 DOI: 10.1007/s00520-026-11029-7

Mechanism Graph

Neiyanggong combines dynamic and static exercises tailored to disease characteristics

↓

Practiced progressively over three chemotherapy cycles

↓

May reduce fatigue and improve sleep through mind-body regulation and physical activity

↓

Result: Significant reduction in fatigue and improvement in sleep quality

Limitations

⚠Single-center study with relatively small sample size (n=72)
⚠No blinding of participants or practitioners due to the nature of the intervention

Frequently Asked Questions

What is Neiyanggong?▼

Neiyanggong is a mind-body exercise combining dynamic and static movements, adapted here as a staged progressive intervention for breast cancer patients.

How was sleep quality measured in this study?▼

Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), which evaluates components like sleep latency, sleep efficiency, and daytime dysfunction.

Did the Neiyanggong group experience any side effects?▼

No adverse events occurred in the Neiyanggong group, and adherence to the intervention was high.

Is this intervention suitable for all breast cancer patients?▼

The study focused on patients undergoing chemotherapy, and the intervention was tailored to disease-specific characteristics. Generalizability may be limited by the single-center design and small sample size.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

1.Du Y, Wang J, Zhang C, Guo Q, Hao X, Zhang W, Jiao G. "Effects of Neiyanggong on cancer-related fatigue in breast cancer patients undergoing chemotherapy: a randomized controlled trial.." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. PMID: 42498825 DOI: 10.1007/s00520-026-11029-7

Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.