Supplements

PeptiSleep™ improves getting to sleep and quality of sleep in adults with sleep impairment

In a randomized, placebo-controlled pilot study, PeptiSleep™, a rice protein hydrolysate, showed nominally significant improvements in getting to sleep (p=0.050) and quality of sleep (p=0.036) as measured by the Leeds Sleep Evaluation Questionnaire. The study was exploratory with a small sample size (n=26) and no adjustments for multiple comparisons.

1 min read•Updated Aug 18, 2026•1 RCTs•View structured evidence →
Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.

PeptiSleep™ improves getting to sleep and quality of sleep in adults with sleep impairment The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).

The Claim

PeptiSleep™ improves getting to sleep and quality of sleep in adults with sleep impairment

This conclusion is most relevant to: Adults aged 18-65 with sleep impairment.

What the Research Shows

The conclusion draws on 1 linked study. Highlights from the cited literature:

  • ▸Effects of PeptiSleep™ on sleep modification and biometrics in adults with sleep impairment: A randomised, placebo-controlled pilot study. (Sleep medicine: X, 2026) —

How It Works

The proposed biological pathway:

  • ▸PeptiSleep™ is a rice protein hydrolysate identified via in silico prediction
  • ▸Contains bioavailable peptides that may modulate sleep-related pathways
  • ▸Ingestion leads to improved sleep initiation and quality
  • ▸Result: Nominally significant improvements in getting to sleep and quality of sleep

Who Might Benefit

Evidence fit by population:

  • ▸Adults aged 18-65 with sleep impairment

Limitations & Caveats

Important context when interpreting this evidence:

  • ▸Small sample size (n=26) and pilot/exploratory design
  • ▸Single-blinded, no adjustments for multiple comparisons on secondary endpoints
  • ▸Objective biometrics were exploratory and not statistically significant

Frequently Asked Questions

What is PeptiSleep™?▼

PeptiSleep™ is a rice protein hydrolysate, a natural compound identified using artificial intelligence and peptide science, designed to improve sleep quality.

How effective is PeptiSleep™ for sleep?▼

In this pilot study, it showed nominally significant improvements in getting to sleep (p=0.050) and quality of sleep (p=0.036) compared to placebo, but results are exploratory and need confirmation in larger trials.

Who was studied in this trial?▼

The study included 26 adults aged 18-65 with self-reported sleep impairment, who were followed for 56 days.

Are there any side effects or safety concerns?▼

The abstract does not report side effects, but the study was small and short-term; more research is needed to establish safety.

References

  1. 1.Mohan NM, Keogh B, Adelfio A, Maldonado R, Rao A, Altini M, Khaldi N, Franklyn-Miller A. “Effects of PeptiSleep™ on sleep modification and biometrics in adults with sleep impairment: A randomised, placebo-controlled pilot study..” Sleep medicine: X, 2026. PMID: 42591960 DOI: 10.1016/j.sleepx.2026.100198
Disclaimer: This article is auto-generated from structured research data for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.