Supplements

PeptiSleep™ improves getting to sleep and quality of sleep in adults with sleep impairment

In a randomized, placebo-controlled pilot study, PeptiSleep™, a rice protein hydrolysate, showed nominally significant improvements in getting to sleep (p=0.050) and quality of sleep (p=0.036) as measured by the Leeds Sleep Evaluation Questionnaire. The study was exploratory with a small sample size (n=26) and no adjustments for multiple comparisons.

Last updated: Aug 18, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effects of PeptiSleep™ on sleep modification and biometrics in adults with sleep impairment: A randomised, placebo-controlled pilot study.

observational

Mohan NM, Keogh B, Adelfio A, Maldonado R, Rao A, Altini M, Khaldi N, Franklyn-Miller A · Sleep medicine: X (2026)

Participants: N/A
Duration: 56 days
Intervention: PeptiSleep™ (rice protein hydrolysate) administered daily for 56 days
Outcome: Sleep quality and getting to sleep (Leeds Sleep Evaluation Questionnaire subscales), mood (Profile of Mood States), sleep diaries, stress, anxiety, sleepiness, insomnia, and biometrics (heart rate variability, sleep architecture, latency via Oura wearable)
Effect Size: N/A (p-values only)
Population: Adults aged 18-65 with sleep impairment

Result:

PubMed: 42591960DOI: 10.1016/j.sleepx.2026.100198

Mechanism Graph

PeptiSleep™ is a rice protein hydrolysate identified via in silico prediction
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Contains bioavailable peptides that may modulate sleep-related pathways
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Ingestion leads to improved sleep initiation and quality
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Result: Nominally significant improvements in getting to sleep and quality of sleep

Limitations

  • ⚠Small sample size (n=26) and pilot/exploratory design
  • ⚠Single-blinded, no adjustments for multiple comparisons on secondary endpoints
  • ⚠Objective biometrics were exploratory and not statistically significant

Frequently Asked Questions

What is PeptiSleep™?▼

PeptiSleep™ is a rice protein hydrolysate, a natural compound identified using artificial intelligence and peptide science, designed to improve sleep quality.

How effective is PeptiSleep™ for sleep?▼

In this pilot study, it showed nominally significant improvements in getting to sleep (p=0.050) and quality of sleep (p=0.036) compared to placebo, but results are exploratory and need confirmation in larger trials.

Who was studied in this trial?▼

The study included 26 adults aged 18-65 with self-reported sleep impairment, who were followed for 56 days.

Are there any side effects or safety concerns?▼

The abstract does not report side effects, but the study was small and short-term; more research is needed to establish safety.

Products

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References

  1. 1.Mohan NM, Keogh B, Adelfio A, Maldonado R, Rao A, Altini M, Khaldi N, Franklyn-Miller A. "Effects of PeptiSleep™ on sleep modification and biometrics in adults with sleep impairment: A randomised, placebo-controlled pilot study.." Sleep medicine: X, 2026. PMID: 42591960 DOI: 10.1016/j.sleepx.2026.100198
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.