Poor sleep quality is associated with higher odds of cognitive impairment in adult hyperthyroid patients
In a cross-sectional study of 406 hyperthyroid patients in Southeast Ethiopia, the prevalence of cognitive impairment was 29.06% (95% CI: 24.84-33.68). Poor sleep quality was significantly associated with increased odds of cognitive impairment (AOR = 2.24), indicating that hyperthyroid patients with poor sleep quality are more than twice as likely to have cognitive impairment compared to those with better sleep quality.
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Poor sleep quality is associated with higher odds of cognitive impairment in adult hyperthyroid patients The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 34/100 (low).
The Claim
Poor sleep quality is associated with higher odds of cognitive impairment in adult hyperthyroid patients
This conclusion is most relevant to: Adult hyperthyroid patients attending Bale zone hospitals, Southeast Ethiopia (n=406).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study. (Health science reports, 2026) —
How It Works
The proposed biological pathway:
- ▸Hyperthyroidism leads to elevated thyroid hormone levels (e.g., FT3), which can affect brain function.
- ▸Elevated thyroid hormones may disrupt sleep quality through metabolic and neurological pathways.
- ▸Poor sleep quality impairs cognitive processes such as memory, attention, and executive function.
- ▸Result: Hyperthyroid patients with poor sleep quality have higher odds of cognitive impairment.
Who Might Benefit
Evidence fit by population:
- ▸Adult hyperthyroid patients attending Bale zone hospitals, Southeast Ethiopia (n=406)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Cross-sectional design cannot establish causality; the association may be bidirectional.
- ▸Sleep quality was not measured with a validated tool (e.g., PSQI) as per abstract; details on assessment are limited.
- ▸Potential confounding factors (e.g., medication use, comorbidities) were not fully controlled for in the analysis.
- ▸Single geographic region (Bale Zone) limits generalizability to other populations.
Frequently Asked Questions
What is the prevalence of cognitive impairment in hyperthyroid patients in this study?▼
The prevalence was 29.06% (95% CI: 24.84-33.68) among 406 adult hyperthyroid patients.
How was cognitive impairment measured in this study?▼
Cognitive impairment was assessed using the Mini Mental State Examination (MMSE) tool.
What is the association between poor sleep quality and cognitive impairment in hyperthyroid patients?▼
Poor sleep quality was associated with higher odds of cognitive impairment (AOR = 2.24), meaning patients with poor sleep quality had more than double the odds of cognitive impairment compared to those with better sleep quality.
What other factors were associated with cognitive impairment in this study?▼
Other associated factors included older age (AOR = 1.09), higher free triiodothyronine (FT3) levels (AOR = 1.03), lower wealth (middle: AOR = 0.18; rich: AOR = 0.19), and avoiding alcohol consumption (AOR = 0.16).
References
- 1.Mihretie ET, Tesfaye G, Sintayehu Y, Ahmed F, Gezahegn B, Serbecha N, Shiferaw Z, Turki A, Desta F. “Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study..” Health science reports, 2026. PMID: 42534581 DOI: 10.1002/hsr2.72902