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Poor sleep quality is associated with higher odds of cognitive impairment in adult hyperthyroid patients

In a cross-sectional study of 406 hyperthyroid patients in Southeast Ethiopia, the prevalence of cognitive impairment was 29.06% (95% CI: 24.84-33.68). Poor sleep quality was significantly associated with increased odds of cognitive impairment (AOR = 2.24), indicating that hyperthyroid patients with poor sleep quality are more than twice as likely to have cognitive impairment compared to those with better sleep quality.

Last updated: Aug 4, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study.

observational

Mihretie ET, Tesfaye G, Sintayehu Y, Ahmed F, Gezahegn B, Serbecha N, Shiferaw Z, Turki A, Desta F · Health science reports (2026)

Participants: N/A
Duration: February to May 2024 (4 months)
Intervention: None (observational study); assessed association between sleep quality and cognitive impairment
Outcome: Cognitive impairment measured by Mini Mental State Examination (MMSE); sleep quality assessed (likely via questionnaire, not specified in abstract)
Effect Size: AOR = 2.24
Population: Adult hyperthyroid patients attending Bale zone hospitals, Southeast Ethiopia (n=406)

Result:

PubMed: 42534581DOI: 10.1002/hsr2.72902

Mechanism Graph

Hyperthyroidism leads to elevated thyroid hormone levels (e.g., FT3), which can affect brain function.
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Elevated thyroid hormones may disrupt sleep quality through metabolic and neurological pathways.
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Poor sleep quality impairs cognitive processes such as memory, attention, and executive function.
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Result: Hyperthyroid patients with poor sleep quality have higher odds of cognitive impairment.

Limitations

  • ⚠Cross-sectional design cannot establish causality; the association may be bidirectional.
  • ⚠Sleep quality was not measured with a validated tool (e.g., PSQI) as per abstract; details on assessment are limited.
  • ⚠Potential confounding factors (e.g., medication use, comorbidities) were not fully controlled for in the analysis.
  • ⚠Single geographic region (Bale Zone) limits generalizability to other populations.

Frequently Asked Questions

What is the prevalence of cognitive impairment in hyperthyroid patients in this study?▼

The prevalence was 29.06% (95% CI: 24.84-33.68) among 406 adult hyperthyroid patients.

How was cognitive impairment measured in this study?▼

Cognitive impairment was assessed using the Mini Mental State Examination (MMSE) tool.

What is the association between poor sleep quality and cognitive impairment in hyperthyroid patients?▼

Poor sleep quality was associated with higher odds of cognitive impairment (AOR = 2.24), meaning patients with poor sleep quality had more than double the odds of cognitive impairment compared to those with better sleep quality.

What other factors were associated with cognitive impairment in this study?▼

Other associated factors included older age (AOR = 1.09), higher free triiodothyronine (FT3) levels (AOR = 1.03), lower wealth (middle: AOR = 0.18; rich: AOR = 0.19), and avoiding alcohol consumption (AOR = 0.16).

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References

  1. 1.Mihretie ET, Tesfaye G, Sintayehu Y, Ahmed F, Gezahegn B, Serbecha N, Shiferaw Z, Turki A, Desta F. "Cognitive Impairment and Associated Factors Among Adult Hyperthyroid Patients at Bale Zone Hospitals, Southeast Ethiopia, 2024: Institution-Based Cross-Sectional Study.." Health science reports, 2026. PMID: 42534581 DOI: 10.1002/hsr2.72902
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.