Quercetin improves night-time sleep in patients with type 2 diabetes mellitus
In a randomized controlled trial, 500 mg quercetin daily for 12 weeks (with a washout and second supplementation period) significantly improved night-time sleep by 11.6% compared to a 7.3% worsening in the control group (p < 0.001). The study included 88 patients with T2DM completing the trial.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Quercetin improves night-time sleep in patients with type 2 diabetes mellitus The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Quercetin improves night-time sleep in patients with type 2 diabetes mellitus
This conclusion is most relevant to: Patients with type 2 diabetes mellitus (T2DM) receiving non-insulin medications.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. (Journal of clinical medicine, 2024) —
How It Works
The proposed biological pathway:
- ▸Quercetin acts as a senolytic with antioxidant activity
- ▸Reduces oxidative stress and inflammation
- ▸May improve metabolic and vascular function
- ▸Result: Improved night-time sleep quality
Who Might Benefit
Evidence fit by population:
- ▸Patients with type 2 diabetes mellitus (T2DM) receiving non-insulin medications
Recommended Dose
500 mg daily
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Open-label study design (not double-blind)
- ▸Relatively small sample size (88 completers)
- ▸Self-reported sleep measure not specified in abstract
Frequently Asked Questions
What dose of quercetin was used to improve sleep in this study?▼
500 mg daily for 12 weeks, with a washout and second supplementation period.
How much did night-time sleep improve with quercetin?▼
Night-time sleep improved by 11.6% in the quercetin group, while it worsened by 7.3% in the control group.
Was this study on people with diabetes?▼
Yes, the study included patients with type 2 diabetes mellitus.
What other benefits did quercetin show in this trial?▼
Quercetin also reduced HbA1c, systolic blood pressure, and anxiety, and improved lung function and quality of life.
References
- 1.Mantadaki AE, Linardakis M, Tsakiri M, Baliou S, Fragkiadaki P, Vakonaki E, Tzatzarakis MN, Tsatsakis A, Symvoulakis EK. “Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial..” Journal of clinical medicine, 2024. PMID: 38930033 DOI: 10.3390/jcm13123504