Supplements

Quercetin improves night-time sleep in patients with type 2 diabetes mellitus

In a randomized controlled trial, 500 mg quercetin daily for 12 weeks (with a washout and second supplementation period) significantly improved night-time sleep by 11.6% compared to a 7.3% worsening in the control group (p < 0.001). The study included 88 patients with T2DM completing the trial.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.

observational

Mantadaki AE, Linardakis M, Tsakiri M, Baliou S, Fragkiadaki P, Vakonaki E, Tzatzarakis MN, Tsatsakis A, Symvoulakis EK · Journal of clinical medicine (2024)

Participants: N/A
Duration: 32 weeks (including washout)
Intervention: 500 mg quercetin daily for 12 weeks, followed by an 8-week washout and a final 12-week supplementation period (total 32 weeks)
Outcome: Night-time sleep (measured via self-report or assessment within the trial)
Effect Size: N/A
Population: Patients with type 2 diabetes mellitus (T2DM) receiving non-insulin medications

Result:

PubMed: 38930033DOI: 10.3390/jcm13123504

Mechanism Graph

Quercetin acts as a senolytic with antioxidant activity
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Reduces oxidative stress and inflammation
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May improve metabolic and vascular function
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Result: Improved night-time sleep quality

Limitations

  • ⚠Open-label study design (not double-blind)
  • ⚠Relatively small sample size (88 completers)
  • ⚠Self-reported sleep measure not specified in abstract

Frequently Asked Questions

What dose of quercetin was used to improve sleep in this study?▼

500 mg daily for 12 weeks, with a washout and second supplementation period.

How much did night-time sleep improve with quercetin?▼

Night-time sleep improved by 11.6% in the quercetin group, while it worsened by 7.3% in the control group.

Was this study on people with diabetes?▼

Yes, the study included patients with type 2 diabetes mellitus.

What other benefits did quercetin show in this trial?▼

Quercetin also reduced HbA1c, systolic blood pressure, and anxiety, and improved lung function and quality of life.

Products

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References

  1. 1.Mantadaki AE, Linardakis M, Tsakiri M, Baliou S, Fragkiadaki P, Vakonaki E, Tzatzarakis MN, Tsatsakis A, Symvoulakis EK. "Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.." Journal of clinical medicine, 2024. PMID: 38930033 DOI: 10.3390/jcm13123504
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.