Standardized lime peel supplement reduces sleep latency and improves sleep efficiency in adults with sleep disturbance
In a randomized, double-blind, placebo-controlled trial, 80 adults with sleep disturbances received either 300 mg/day of standardized lime peel supplement (SLPS) or placebo for 2 weeks. SLPS significantly improved polysomnographic outcomes including reduced sleep latency, wake after sleep onset, and total wake time, as well as enhanced sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness measured by the Epworth Sleepiness Scale was also decreased, with no serious adverse effects reported.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Standardized lime peel supplement reduces sleep latency and improves sleep efficiency in adults with sleep disturbance The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Standardized lime peel supplement reduces sleep latency and improves sleep efficiency in adults with sleep disturbance
This conclusion is most relevant to: Adults with sleep disturbances (80 subjects).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study. (Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025) —
How It Works
The proposed biological pathway:
- ▸SLPS activates GABAA receptors
- ▸Induces non-rapid eye movement sleep
- ▸Shortens sleep latency
- ▸Result: Improved sleep quality and reduced daytime sleepiness
Who Might Benefit
Evidence fit by population:
- ▸Adults with sleep disturbances (80 subjects)
Recommended Dose
300 mg/day
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Short intervention period of only 2 weeks, limiting long-term efficacy and safety assessment
- ▸Specific effect sizes (e.g., Cohen's d) not reported in the abstract, making magnitude of effect unclear
Frequently Asked Questions
What is standardized lime peel supplement (SLPS)?▼
SLPS is a supplement derived from citrus peels rich in flavonoids, standardized for consistency, and tested for sedative-hypnotic effects in both animal and human studies.
How does SLPS improve sleep?▼
SLPS is believed to activate GABAA receptors, similar to some sleep medications, inducing non-rapid eye movement sleep and reducing sleep latency based on prior animal research.
Is SLPS safe for long-term use?▼
This study only lasted 2 weeks and reported no serious adverse effects, but long-term safety data are not yet available from this trial.
Who might benefit from taking SLPS?▼
Adults with sleep disturbances, such as difficulty falling asleep or staying asleep, may benefit, but the study did not specify severity levels of sleep disturbance.
References
- 1.Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S. “Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study..” Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025. PMID: 39970858 DOI: 10.1016/j.phymed.2025.156510