Supplements

Standardized lime peel supplement reduces sleep latency and improves sleep efficiency in adults with sleep disturbance

In a randomized, double-blind, placebo-controlled trial, 80 adults with sleep disturbances received either 300 mg/day of standardized lime peel supplement (SLPS) or placebo for 2 weeks. SLPS significantly improved polysomnographic outcomes including reduced sleep latency, wake after sleep onset, and total wake time, as well as enhanced sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness measured by the Epworth Sleepiness Scale was also decreased, with no serious adverse effects reported.

Last updated: Jul 7, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.

observational

Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S · Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)

Participants: N/A
Duration: 2 weeks
Intervention: 300 mg/day standardized lime peel supplement (SLPS) for 2 weeks
Outcome: Polysomnographic measures (sleep latency, wake after sleep onset, total wake time, sleep efficiency, total sleep time, stage 2 sleep) and daytime sleepiness (Epworth Sleepiness Scale)
Effect Size: N/A
Population: Adults with sleep disturbances (80 subjects)

Result:

PubMed: 39970858DOI: 10.1016/j.phymed.2025.156510

Mechanism Graph

SLPS activates GABAA receptors
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Induces non-rapid eye movement sleep
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Shortens sleep latency
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Result: Improved sleep quality and reduced daytime sleepiness

Limitations

  • ⚠Short intervention period of only 2 weeks, limiting long-term efficacy and safety assessment
  • ⚠Specific effect sizes (e.g., Cohen's d) not reported in the abstract, making magnitude of effect unclear

Frequently Asked Questions

What is standardized lime peel supplement (SLPS)?▼

SLPS is a supplement derived from citrus peels rich in flavonoids, standardized for consistency, and tested for sedative-hypnotic effects in both animal and human studies.

How does SLPS improve sleep?▼

SLPS is believed to activate GABAA receptors, similar to some sleep medications, inducing non-rapid eye movement sleep and reducing sleep latency based on prior animal research.

Is SLPS safe for long-term use?▼

This study only lasted 2 weeks and reported no serious adverse effects, but long-term safety data are not yet available from this trial.

Who might benefit from taking SLPS?▼

Adults with sleep disturbances, such as difficulty falling asleep or staying asleep, may benefit, but the study did not specify severity levels of sleep disturbance.

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References

  1. 1.Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S. "Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.." Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025. PMID: 39970858 DOI: 10.1016/j.phymed.2025.156510
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.