TruCBN™ shows no adverse effects in oral toxicity studies in rats up to 400 mg/kg/day
In 14-day and 90-day repeat-dose oral toxicity studies in Sprague-Dawley rats, TruCBN™ at doses of 100, 200, and 400 mg/kg/day produced no adverse clinical signs, body weight changes, food consumption effects, or clinical pathology changes. The no-observed-adverse-effect-level (NOAEL) was determined to be 400 mg/kg/day.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
TruCBN™ shows no adverse effects in oral toxicity studies in rats up to 400 mg/kg/day The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
TruCBN™ shows no adverse effects in oral toxicity studies in rats up to 400 mg/kg/day
This conclusion is most relevant to: Male and female Sprague-Dawley rats.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Investigation into the oral toxicity profile of TruCBN™. (Toxicology reports, 2026) —
How It Works
The proposed biological pathway:
- ▸CBN acts as a low affinity partial agonist at CB1 and CB2 receptors
- ▸Greater affinity for CB2 receptors
- ▸CBN is an oxidative decomposition product of CBD and THC
- ▸No observed toxicological effects at tested doses
Who Might Benefit
Evidence fit by population:
- ▸Male and female Sprague-Dawley rats
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study, not directly translatable to humans
- ▸Only tested up to 90 days, long-term effects unknown
- ▸No sleep quality outcomes measured in this study
Frequently Asked Questions
What is TruCBN™?▼
TruCBN™ is a proprietary high-purity form of cannabinol (CBN) processed to be substantially free of THC.
What is the NOAEL for TruCBN™ in rats?▼
The no-observed-adverse-effect-level (NOAEL) is 400 mg/kg/day based on the 90-day oral toxicity study.
Does this study show that CBN is safe for humans?▼
No, this is an animal study in rats; human safety requires clinical trials.
What are the potential therapeutic uses of CBN mentioned?▼
Potential uses include ocular disease, neuroprotection, antimicrobial, anti-inflammatory, immunosuppressive effects, and sleep quality improvement.
References
- 1.Bauter MR, Hartung V, Dunn C, Jensen RP, McCormick M, Roberts M, DiCarlo-Emery D. “Investigation into the oral toxicity profile of TruCBN™..” Toxicology reports, 2026. PMID: 42383225 DOI: 10.1016/j.toxrep.2026.102296