Supplements

A multispecies probiotic intervention improves sleep quality in individuals with self-reported sleep disturbances

In a randomized, double-blind, placebo-controlled trial, 94 participants with poor sleep quality (PSQI > 5) received either a multispecies probiotic (OMNiBiOTiC® STRESS Repair) or placebo for 28 days. The probiotic group showed a significantly greater improvement in sleep quality (PSQI score 6.8 ± 2.9 vs. 7.7 ± 3.1; p = 0.036) compared to placebo, driven by improvements in sleep efficiency and latency.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. The beneficial effect of a multispecies probiotic intervention on quality of sleep - a randomized, double-blinded, placebo-controlled study.

observational

Horvath A, Haller R, Schmid-Zalaudek K, Goswami N, Wagner-Skacel J, Habisch H, Madl T, Stadlbauer V · Journal of psychiatric research (2026)

Participants: N/A
Duration: 28 days
Intervention: Multispecies probiotic (OMNiBiOTiC® STRESS Repair) for 28 days
Outcome: Sleep quality measured by PSQI score, sleep efficiency, sleep latency
Effect Size: N/A (only p-value reported: p = 0.036)
Population: 130 volunteers with self-reported impaired sleep quality (PSQI > 5); 94 completers (88% female, mean age ~41 years)

Result:

PubMed: 41637999DOI: 10.1016/j.jpsychires.2026.01.040

Mechanism Graph

Probiotic bacteria are ingested and partially recovered in the gut microbiome
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Microbiome composition shifts (beta diversity change)
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Gut-brain axis modulation influences circadian rhythms
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Improved sleep efficiency and latency, leading to better overall sleep quality

Limitations

  • ⚠High dropout rate (36 of 130 participants did not complete the study)
  • ⚠Predominantly female sample (88%), limiting generalizability to males
  • ⚠No significant effect on quality of life or perceived stress, suggesting specific rather than broad benefits

Frequently Asked Questions

What probiotic was used in this study?▼

The study used a multispecies probiotic called OMNiBiOTiC® STRESS Repair.

How long did the probiotic intervention last?▼

The intervention lasted 28 days.

Did the probiotic improve stress or quality of life?▼

No, the intervention did not significantly influence quality of life or perceived stress.

What was the main sleep improvement observed?▼

The probiotic improved sleep efficiency and latency, leading to a lower PSQI score (better sleep quality) compared to placebo.

Products

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References

  1. 1.Horvath A, Haller R, Schmid-Zalaudek K, Goswami N, Wagner-Skacel J, Habisch H, Madl T, Stadlbauer V. "The beneficial effect of a multispecies probiotic intervention on quality of sleep - a randomized, double-blinded, placebo-controlled study.." Journal of psychiatric research, 2026. PMID: 41637999 DOI: 10.1016/j.jpsychires.2026.01.040
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.