LifestyleExercise

Company cafeteria use, regular exercise, and breakfast consumption are associated with reduced hyperuricemia risk, while smoking and breakfast skipping increase risk among male manufacturing workers

In a cross-sectional study of 613 male manufacturing workers in Japan, 20.6% had high uric acid (≥7.0 mg/dL). Multivariable logistic regression identified smoking (OR=1.861), skipping breakfast ≥3 times/week (OR=1.684), and higher ALT (OR=1.035) as risk factors, while company cafeteria use (OR=0.528), regular exercise (OR=0.501), older age (OR=0.952), and higher eGFR (OR=0.969) were protective.

Last updated: Aug 2, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Workplace Environment and Lifestyle Factors Associated With Hyperuricemia Risk Among Male Manufacturing Workers: A Cross-Sectional Study at a Single Company in Japan.

observational

Takahashi Y, Tanojiri R, Kumakura R, Okamoto R, Yu S, Omote S · Cureus (2026)

Participants: N/A
Duration: Cross-sectional (single time point in June 2025)
Intervention: Observational assessment of workplace environment (job type, lunch type, fluid intake) and lifestyle factors (breakfast skipping, exercise, smoking, alcohol, sleep)
Outcome: Serum uric acid level ≥7.0 mg/dL (hyperuricemia)
Effect Size: OR=1.861 for smoking, OR=1.684 for breakfast skipping, OR=0.528 for cafeteria use, OR=0.501 for exercise
Population: 613 male workers at a single manufacturing company in Japan (≥1,000 employees, no night shifts), mean age 39.9 years

Result:

PubMed: 42524050DOI: 10.7759/cureus.111627

Mechanism Graph

Smoking may increase oxidative stress and purine metabolism
↓
Breakfast skipping may alter metabolic regulation and insulin sensitivity
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Company cafeteria use may provide healthier meal options
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Regular exercise improves metabolic health and uric acid excretion

Limitations

  • ⚠Cross-sectional design prevents causal inference
  • ⚠Single company and male-only sample limits generalizability
  • ⚠Self-reported questionnaire data may introduce recall bias
  • ⚠No night shift workers included, limiting applicability to shift workers

Frequently Asked Questions

What is the main finding of this study?▼

Company cafeteria use, regular exercise, and not skipping breakfast were associated with lower hyperuricemia risk, while smoking and frequent breakfast skipping increased risk among male manufacturing workers.

How many participants had high uric acid?▼

126 out of 613 participants (20.6%) had serum uric acid levels ≥7.0 mg/dL.

What lifestyle factors were examined?▼

Breakfast skipping, exercise habits, smoking, alcohol consumption, and sleep duration were assessed via questionnaire.

What workplace factors were studied?▼

Job type, lunch type (company cafeteria vs. other), and fluid intake were evaluated as workplace environment factors.

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References

  1. 1.Takahashi Y, Tanojiri R, Kumakura R, Okamoto R, Yu S, Omote S. "Workplace Environment and Lifestyle Factors Associated With Hyperuricemia Risk Among Male Manufacturing Workers: A Cross-Sectional Study at a Single Company in Japan.." Cureus, 2026. PMID: 42524050 DOI: 10.7759/cureus.111627
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.