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Longer sleep onset latency is significantly correlated with lower time in range in adults with cystic fibrosis-related diabetes

In a remote pilot study of 30 adults with CFRD, longer sleep onset latency measured by actigraphy was significantly correlated with lower time in range (TIR), indicating worse glycemic control. The study found that 76.7% of participants reported poor sleep quality, with 46.7% endorsing clinically significant insomnia symptoms.

Last updated: Jul 25, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Sleep patterns and glycemia in adults with cystic fibrosis-related diabetes: a remote pilot study.

observational

Sharma A, Vassilakis E, Deng H, Salwen-Deremer JK, Bartley BL, Putman MS, Dashti HS · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2026)

Participants: N/A
Duration: 10 days
Intervention: Observational; no intervention tested
Outcome: Sleep onset latency (actigraphy), time in range (continuous glucose monitoring)
Effect Size: N/A (correlation reported but no effect size given in abstract)
Population: Adults with cystic fibrosis-related diabetes (mean age 43.7 years, 83.3% female, 93.3% White)

Result:

PubMed: 42457443DOI: 10.1016/j.jcf.2026.07.005

Mechanism Graph

Sleep disturbance is prevalent in cystic fibrosis
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Sleep disturbance may contribute to dysglycemia in CFRD
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Longer sleep onset latency was measured via actigraphy
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Longer sleep onset latency correlated with lower time in range

Limitations

  • ⚠Small sample size (n=30) limits generalizability
  • ⚠Observational design cannot establish causality
  • ⚠High proportion of female and White participants may limit applicability to other demographics

Frequently Asked Questions

What is the main finding of this study?▼

The study found that longer sleep onset latency is significantly correlated with lower time in range (a measure of glycemic control) in adults with cystic fibrosis-related diabetes.

How was sleep measured in this study?▼

Sleep was measured using wrist actigraphy, which provided estimates of sleep duration, efficiency, and onset latency, along with validated surveys for sleep quality and disorders.

What percentage of participants had poor sleep quality?▼

76.7% of participants reported poor overall sleep quality, and 46.7% had clinically significant insomnia symptoms.

Is this study applicable to all people with cystic fibrosis?▼

The study focused on adults with CFRD, and the sample was predominantly female and White, so results may not generalize to other populations or those without diabetes.

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References

  1. 1.Sharma A, Vassilakis E, Deng H, Salwen-Deremer JK, Bartley BL, Putman MS, Dashti HS. "Sleep patterns and glycemia in adults with cystic fibrosis-related diabetes: a remote pilot study.." Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2026. PMID: 42457443 DOI: 10.1016/j.jcf.2026.07.005
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.