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MobACT, a guided internet-based Acceptance and Commitment Therapy programme, may improve pain acceptance in Italian adults with chronic pain.

This study protocol describes a two-arm randomized controlled trial evaluating the effectiveness and cost-effectiveness of MobACT, a guided internet-based ACT intervention, for Italian adults with medically verified chronic pain. The primary outcome is pain acceptance measured by the Chronic Pain Acceptance Questionnaire at post-intervention (T1), with secondary outcomes including pain intensity, pain interference, sleep quality, and psychological flexibility. The trial compares immediate MobACT to a waitlist control, with a 6-month follow-up in the intervention group only.

Last updated: Jul 30, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effectiveness and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy intervention (MobACT) for adults with Chronic Pain in Italy: study protocol for a randomized controlled trial.

observational

Semonella M, De Luca A, Rodighiero C, Andersson G, Buhrman M, Donisi V, Guerrini Usubini A, Landi G, Manna C, Pasini I, Perlini C, Pietrabissa G, Segattini B, Tossani E, Grandi S, Del Piccolo L, Castelnuovo G · Frontiers in psychology (2026)

Participants: N/A
Duration: 6 months follow-up
Intervention: Guided internet-based Acceptance and Commitment Therapy (ACT) programme (MobACT)
Outcome: Pain acceptance (Chronic Pain Acceptance Questionnaire), pain intensity, pain interference, sleep quality, quality of life, central sensitization, pain catastrophizing, psychological flexibility, self-efficacy, coping, anxiety, depressive symptoms
Effect Size: N/A
Population: Italian adults with medically verified chronic pain

Result:

PubMed: 42516192DOI: 10.3389/fpsyg.2026.1813251

Mechanism Graph

Participants receive guided internet-based ACT sessions
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Participants engage in acceptance and mindfulness exercises
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Participants develop psychological flexibility and reduce experiential avoidance
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Result: Improved pain acceptance and reduced pain interference

Limitations

  • ⚠The waitlist control design may overestimate treatment effects due to expectancy bias
  • ⚠Only the intervention group has a 6-month follow-up, limiting long-term comparison
  • ⚠The study is a protocol; results are not yet available

Frequently Asked Questions

What is MobACT?▼

MobACT is a guided internet-based Acceptance and Commitment Therapy programme designed for Italian adults with chronic pain.

What is the primary outcome of this trial?▼

The primary outcome is pain acceptance, measured by the Chronic Pain Acceptance Questionnaire at post-intervention.

Who can participate in this study?▼

Italian adults with medically verified chronic pain are eligible for this randomized controlled trial.

How long is the follow-up period?▼

The intervention group has a 6-month follow-up (T2), while the waitlist control group receives MobACT only after the primary assessment (T1).

Products

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References

  1. 1.Semonella M, De Luca A, Rodighiero C, Andersson G, Buhrman M, Donisi V, Guerrini Usubini A, Landi G, Manna C, Pasini I, Perlini C, Pietrabissa G, Segattini B, Tossani E, Grandi S, Del Piccolo L, Castelnuovo G. "Effectiveness and cost-effectiveness of a guided internet-based Acceptance and Commitment Therapy intervention (MobACT) for adults with Chronic Pain in Italy: study protocol for a randomized controlled trial.." Frontiers in psychology, 2026. PMID: 42516192 DOI: 10.3389/fpsyg.2026.1813251
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.